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Showing 4816 to 4830 of 7690 results

  1. NICE encourages further research into CXL using riboflavin and UVA for keratoconus and keratectasia, especially epithelium-on (transepithelial) CXL and the combination (CXL-plus) procedures. Details of the techniques used should be clearly described. Reported outcomes should include visual acuity, corneal topography and quality of life. Data on long-term outcomes for all types of CXL using riboflavin and UVA for keratoconus and keratectasia would be useful – specifically data about prevention of progression to corneal transplantation and about repeat procedures and their efficacy.

    Recommendation ID IPG466/1 Question NICE encourages further research into CXL using riboflavin and UVA for keratoconus and keratectasia

    Research recommendation
    Published
    9 June 2015

  2. NICE recommends that robust evidence be generated to show the clinical effectiveness of pharmacokinetic dose adjustment of continuous infusion 5-FU in people with colorectal cancer.

    Recommendation ID DG16/2 Question NICE recommends that robust evidence be generated to show the clinical effectiveness of pharmacokinetic

    Research recommendation
    Published
    9 June 2015

  3. Non-invasive tests for diagnosing NAFLD and advanced liver fibrosis in children and young people:- Which non-invasive tests most accurately diagnose NAFLD and advanced liver fibrosis in children and young people?

    Recommendation ID NG49/3 Question Non-invasive tests for diagnosing NAFLD and advanced liver fibrosis in children and young people:- Which

    Research recommendation
    Published
    24 August 2016

  4. Non-invasive tests for diagnosing NAFLD in adults:- Which non-invasive tests are most accurate and cost-effective in identifying non-alcoholic fatty liver disease (NAFLD) in adults with risk factors, type 2 diabetes and metabolic syndrome?

    Recommendation ID NG49/1 Question Non-invasive tests for diagnosing NAFLD in adults:- Which non-invasive tests are most accurate and cost-effective

    Research recommendation
    Published
    24 August 2016

  5. Non-invasive tests for diagnosing NASH:- Which non-invasive tests most accurately identify non-alcoholic steatohepatitis (NASH) in people with non-alcoholic fatty liver disease (NAFLD)?

    Recommendation ID NG49/2 Question Non-invasive tests for diagnosing NASH:- Which non-invasive tests most accurately identify non-alcoholic

    Research recommendation
    Published
    24 August 2016

  6. What is the effectiveness of high-pressure non-invasive positive pressure ventilation (NIPPV) compared with continuous positive airways pressure (CPAP) flow driver as the primary mode of ventilation?

    Recommendation ID NG124/1 Question What is the effectiveness of high-pressure non-invasive positive pressure ventilation (NIPPV) compared

    Research recommendation
    Published
    16 August 2019

  7. Non-pharmacological interventions for patients with an acute painful sickle cell episode:- For patients with an acute painful sickle cell episode, are non-pharmacological interventions, such as massage, effective in improving their recovery from the episode?

    Recommendation ID CG143/4 Question Non-pharmacological interventions for patients with an acute painful sickle cell episode:- For patients

    Research recommendation
    Published
    9 June 2015

  8. What is the clinical and cost effectiveness of antibiotics for the management of acute diverticulitis in primary care?

    Recommendation ID NG147/1 Question What is the clinical and cost effectiveness of antibiotics for the management of acute diverticulitis

    Research recommendation
    Published
    10 February 2020

  9. Nutritional support after radical surgery:- What is the optimal method of delivering nutritional support to adults after surgery with curative intent for oesophago-gastric cancer?

    Recommendation ID NG83/3 Question Nutritional support after radical surgery:- What is the optimal method of delivering nutritional support

    Research recommendation
    Published
    13 November 2018

  10. Nutrition:- Does a high calorific diet prolong survival of people with motor neurone disease (MND) if initiated following diagnosis or following initiation of feeding using a gastrostomy?

    Recommendation ID NG42/5 Question Nutrition:- Does a high calorific diet prolong survival of people with motor neurone disease (MND) if

    Research recommendation
    Published
    21 March 2016

  11. Is obesity an independent risk factor for perinatal morbidity and mortality?

    Recommendation ID NG121/3 Question Is obesity an independent risk factor for perinatal morbidity and mortality? Any explanatory

    Research recommendation
    Published
    16 August 2019

  12. Cancers insufficiently researched in primary care: Observational studies of symptomatic primary care patients should be used to estimate the positive predictive value of different symptoms for specific cancers. Priority areas for research are those where the evidence base is currently insufficient and should include prostate cancer, pancreatic cancer, cancer in childhood and young people and other rare cancers. Outcomes of interest are positive predictive values and likelihood ratios for cancer.

    Recommendation ID NG131/03 Question Cancers insufficiently researched in primary care: Observational studies of symptomatic primary care

    Research recommendation
    Published
    7 January 2022

  13. Oesophagectomy: What is the effectiveness of endoscopic resection with or without adjuvant chemoradiotherapy and oesophagectomy for adults with T1b oesophageal adenocarcinoma?

    Recommendation ID NG231/03 Question Oesophagectomy: What is the effectiveness of endoscopic resection with or without adjuvant chemoradiotherapy

    Research recommendation
    Published
    9 March 2023

  14. Older people's experiences:- What is the lived experience of older people with social care needs and multiple long-term conditions?

    Recommendation ID NG22/1 Question Older people's experiences:- What is the lived experience of older people with social care needs and

    Research recommendation
    Published
    11 December 2015

  15. Evidence on the efficacy of open prenatal repair of open neural tube defects in the fetus is adequate in quantity and quality. However, evidence on its safety shows serious but well recognised safety concerns for the mother and fetus. Therefore, this procedure should only be used with  special arrangements   for clinical governance, consent, and audit or research.

    Recommendation ID IPG668 Question Evidence on the efficacy of open prenatal repair of open neural tube defects in the fetus is adequate

    Research recommendation
    Published
    10 February 2020