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Showing 4996 to 5010 of 7688 results

  1. Epiretinal brachytherapy for wet age-related macular degeneration (AMD) should only be used in the context of research. Research studies should address whether epiretinal brachytherapy reduces the progression of wet AMD and whether it can reduce the number of injections of antivascular endothelial growth factor agents (anti-VEGF) required. Long-term outcomes should be reported.

    Recommendation ID IPG415/1 Question Epiretinal brachytherapy for wet age-related macular degeneration (AMD) should only be used in the

    Research recommendation
    Published
    9 June 2015

  2. Episcissors-60 show promise for mediolateral episiotomy. But there is currently not enough evidence to support the case for routine adoption in the NHS. Research is recommended to address uncertainties about the efficacy and safety of using Episcissors-60. This research should: - determine if using Episcissors-60 in addition to other care bundle measures is more effective in achieving an optimal episiotomy angle and in preventing episiotomy-related obstetric anal sphincter injuries (OASI) than standard episiotomy scissors - include patient-reported outcome measures - address potential equality considerations by ensuring patients at greatest risk of OASI are recruited - determine the relative cost of using Episcissors-60 compared with standard episiotomy scissors.

    Recommendation ID MTG47/1 Question Episcissors-60 show promise for mediolateral episiotomy. But there is currently not enough evidence

    Research recommendation
    Published
    17 March 2020

  3. Evaluation frameworks and logic models:- Which evaluation frameworks and logic models can be used to evaluate the impact of community engagement on health and wellbeing?

    Recommendation ID NG44/2 Question Evaluation frameworks and logic models:- Which evaluation frameworks and logic models can be used to

    Research recommendation
    Published
    6 April 2016

  4. Evaluation of extensively used interventions:- Evaluate currently unevaluated but extensively used interventions for attachment difficulties.

    Recommendation ID NG26/3 Question Evaluation of extensively used interventions:- Evaluate currently unevaluated but extensively used interventions

    Research recommendation
    Published
    11 December 2015

  5. Evidence is adequate on the short-term safety and efficacy of personalised external aortic root support (PEARS) using mesh to prevent aortic root expansion and aortic dissection in people with Marfan syndrome. Evidence on long-term outcomes is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page. Further research should report details of patient selection, including aortic diameter, and long-term outcomes, including evidence of disease progression, such as dilation and dissection of the aortic root.

    Recommendation ID IPG724/01 Question Evidence is adequate on the short-term safety and efficacy of personalised external aortic root support

    Research recommendation
    Published
    31 May 2022

  6. Evidence on the efficacy and safety of neurostimulation of lumbar muscles for refractory non-specific chronic low back pain is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG739/01 Question Evidence on the efficacy and safety of neurostimulation of lumbar muscles for refractory non-specific

    Research recommendation
    Published
    30 September 2022

  7. Evidence on the efficacy of bioresorbable stent implantation to treat coronary artery disease is inadequate. Evidence on its safety has shown an increased risk of serious complications in the longer term. This includes an increased risk of myocardial infarction and death with some types of bioresorbable stents. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG732/01 Question Evidence on the efficacy of bioresorbable stent implantation to treat coronary artery disease is inadequate

    Research recommendation
    Published
    7 September 2022

  8. Evidence on the efficacy of focal resurfacing implants to treat articular cartilage damage in the knee is limited in quality and quantity. Short-term evidence shows no major safety concerns, but long-term evidence on safety is limited in quality and quantity. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG734/01 Question Evidence on the efficacy of focal resurfacing implants to treat articular cartilage damage in the

    Research recommendation
    Published
    7 September 2022

  9. Diagnosing asthma in adults (aged 17 and over):- What is the clinical and cost effectiveness of using an indirect bronchial challenge test with mannitol to diagnose asthma in adults (aged 17 and over)?

    Recommendation ID NG80/2 Question Diagnosing asthma in adults (aged 17 and over):- What is the clinical and cost effectiveness of using

    Research recommendation
    Published
    18 October 2018

  10. Diagnosing asthma in children and young people aged 5 to 16:- What is the acceptability and diagnostic accuracy of objective tests that could be used to comprisea diagnostic pathway for asthma in children and young people aged 5 to 16 (for example, exercise challenge, direct bronchial challenge with histamine or methacholine, indirect bronchial challenge with mannitol and peripheral blood eosinophil count)?

    Recommendation ID NG80/1 Question Diagnosing asthma in children and young people aged 5 to 16:- What is the acceptability and diagnostic

    Research recommendation
    Published
    18 October 2018

  11. In patients with negative MRI (Likert score 1 or 2), what is the next best diagnostic investigation to rule out clinically significant prostate cancer? What is the diagnostic accuracy of transperineal mapping biopsy compared with transperineal non-mapping biopsy in the diagnosis of clinically significant prostate cancer?

    Recommendation ID NG131/7 Question In patients with negative MRI (Likert score 1 or 2), what is the next best diagnostic investigation

    Research recommendation
    Published
    25 October 2019

  12. What is the prognostic value of different risk stratification methods for people with locally advanced prostate cancer?

    Recommendation ID NG131/7 Question What is the prognostic value of different risk stratification methods for people with locally advanced

    Research recommendation
    Published
    25 October 2019

  13. Apart from culture, what other diagnostic tests or combinations of tests are effective inestablishing an accurate diagnosis of active respiratory TB in children and young people withsuspected active TB?

    Recommendation ID NG33/2 Question Apart from culture, what other diagnostic tests or combinations of tests are effective inestablishing

    Research recommendation
    Published
    8 November 2019

  14. What is the most clinically and cost-effective pathway for diagnosing clinically significant prostate cancer?

    Recommendation ID NG131/3 Question What is the most clinically and cost-effective pathway for diagnosing clinically significant prostate

    Research recommendation
    Published
    25 October 2019

  15. Primary care testing: Diagnostic accuracy studies of tests accessible to primary care should be carried out for a given cancer in symptomatic people. Priority areas for research should include tests for people with cough, non-visible haematuria, suspected prostate cancer, suspected pancreatic cancer, suspected cancer in childhood and young people and other suspected rare cancers. Outcomes of interest are the performance characteristics of the test, particularly sensitivity, specificity and positive and negative predictive values.

    Recommendation ID NG12/02 Question Primary care testing: Diagnostic accuracy studies of tests accessible to primary care should be carried

    Research recommendation
    Published
    7 January 2022