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This guidance has been replaced by NICE guideline CG81.
Ruxolitinib for disease-related splenomegaly or symptoms in adults with myelofibrosis (TA289)
This guidance has been updated and replaced by NICE technology appraisal guidance 386.
Pegloticase for treating severe debilitating chronic tophaceous gout (TA291)
The guidance has been withdrawn because pegloticase (Krystexxa) no longer has a marketing authorisation. See the European Medicines Agency product information.
Lubiprostone for treating chronic idiopathic constipation (TA318)
This guidance has been withdrawn because Takeda has discontinued lubiprostone (Amitiza).
This guidance has been updated and replaced by NICE technology appraisal guidance TA421.
This guideance has been updated and replaced by NICE technology appraisal guidance 422.
We have withdrawn this guidance. Inceptua has stopped marketing Ocriplasmin (Jetrea) and its marketing authorisation has been withdrawn.
This guidance has been updated and replaced by NICE technology appraisal guidance 402.
The clinical effectiveness and cost effectiveness of sibutramine for obesity (TA31)
This guidance has been replaced by NICE guideline CG43.
This guidance has been updated and replaced by NICE technology appraisal guidance 375.
This guidance has been updated and replaced by NICE technology appraisal guidance 301.
This guidance has been updated and replaced by NICE guideline NG28.
Eribulin for the treatment of locally advanced or metastatic breast cancer (TA250)
This guidance has been updated and replaced by NICE technology appraisal guidance 423 and NICE technology appraisal guidance 515.
This guidance has been updated and replaced by NICE technology appraisal guidance 426.
Guidance on the use of gemcitabine for the treatment of pancreatic cancer (TA25)
This guidance has been replaced by NICE guideline NG85.