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Guidance programme

Advice programme

Showing 4381 to 4395 of 7679 results

  1. NICE encourages further research into preoperative high dose rate brachytherapy for rectal cancer. Trials should be designed to provide clear data on the efficacy of this procedure, whether or not other adjunctive treatments are used. Research should document adjunctive treatments and details of patient selection. Outcomes should include local recurrence, survival, disease-free survival and quality of life. NICE may update the guidance on publication of further evidence.

    Recommendation ID IPG531/1 Question NICE encourages further research into preoperative high dose rate brachytherapy for rectal cancer.

    Research recommendation
    Published
    12 October 2015

  2. Newly diagnosed seizures (focal and generalised) – monotherapy: How do the newer AEDs compare in efficacy to the standard AEDs in the treatment of newly diagnosed epilepsy? Focal seizures: carbamazepine, eslicarbazepine acetate, lacosamide, lamotrigine, levetiracetam, pregabalin  and zonisamide. Generalised seizures: lamotrigine, levetiracetam, sodium valproate and zonisamide.

    Recommendation ID CG137/1 Question Newly diagnosed seizures (focal and generalised) – monotherapy: How do the newer AEDs compare in efficacy

    Research recommendation
    Published
    13 August 2021

  3. NICE encourages further research into ultrasound-enhanced, catheter-directedthrombolysis for pulmonary embolism. Ideally this should include comparative studies against catheter-directed thrombolysis alone. Patient selection should be  documented. The dose of thrombolytic agent used and the duration of thrombolysis should be reported, together with all complications. Outcome measures should include the success of thrombolysis (complete, partial or failed) and long-term sequelae. NICE may update the guidance on publication of further evidence.

    Recommendation ID IPG524/1 Question NICE encourages further research into ultrasound-enhanced, catheter-directedthrombolysis for pulmonary

    Research recommendation
    Published
    6 October 2015

  4. NICE encourages further research into radiofrequency ablation for gastric antral vascular ectasia and collaborative publication of data from local audit. Patient selection should be clearly documented, including details of prior treatments. Outcomes should include success and duration of effect in controlling bleeding and the effect of this on the need for blood transfusion. All complications should be reported. NICE may update the guidance on publication of further evidence.

    Recommendation ID IPG520/1 Question NICE encourages further research into radiofrequency ablation for gastric antral vascular ectasia and

    Research recommendation
    Published
    6 October 2015

  5. NICE encourages further research into CXL using riboflavin and UVA for keratoconus and keratectasia, especially epithelium-on (transepithelial) CXL and the combination (CXL-plus) procedures. Details of the techniques used should be clearly described. Reported outcomes should include visual acuity, corneal topography and quality of life. Data on long-term outcomes for all types of CXL using riboflavin and UVA for keratoconus and keratectasia would be useful – specifically data about prevention of progression to corneal transplantation and about repeat procedures and their efficacy.

    Recommendation ID IPG466/1 Question NICE encourages further research into CXL using riboflavin and UVA for keratoconus and keratectasia

    Research recommendation
    Published
    9 June 2015

  6. NICE agreed that further research was needed because there is currently no clinical- or cost-effectiveness evidence evaluating the use of Holoclar in both eyes in bilateral patients. The committee was aware of the ongoing HOLOCORE trial which is recruiting both unilateral and bilateral patients, but only evaluates the success of a second transplant in 1 eye rather than transplant success in both eyes.

    Recommendation ID TA467/1 Question NICE agreed that further research was needed because there is currently no clinical- or cost-effectiveness

    Research recommendation
    Published
    15 October 2018

  7. NICE agreed that further research would be of value to investigate factors which can predict the likelihood of rapid progression of disease and response to treatment with biological DMARDs. Factors to investigate include:- persistent elevation of inflammatory markers (such as C-reactive protein [CRP]) and- presence of erosions on X-ray and- positive for anti-citrullinated protein antibodies (ACPA).

    Recommendation ID TA375/1 Question NICE agreed that further research would be of value to investigate factors which can predict the likelihood

    Research recommendation
    Published
    15 March 2016

  8. NICE encourages further research into efficacy of extracorporeal membrane oxygenation (ECMO) for acute heart failure. This should include clear documentation of patient selection and indications for the use of ECMO. Outcome measures should include survival, quality of life and neurological status.

    Recommendation ID IPG482/1 Question NICE encourages further research into efficacy of extracorporeal membrane oxygenation (ECMO) for acute

    Research recommendation
    Published
    9 June 2015

  9. NICE encourages further research into radiofrequency ablation of the soft palate for snoring. This could take the form of data collection, with the specific aim of documenting long-term outcomes and the need for further treatment.

    Recommendation ID IPG476/1 Question NICE encourages further research into radiofrequency ablation of the soft palate for snoring. This

    Research recommendation
    Published
    9 June 2015

  10. NICE encourages further research on corticosteroid-eluting bioabsorbable stent or spacer insertion during endoscopic sinus surgery and, specifically, controlled studies designed for between-patient (rather than within-patient) comparisons. Outcomes should include symptom scores, quality of life and the need for retreatment in the long term. All complications should be reported. NICE may update this guidance on publication of further evidence.

    Recommendation ID IPG551/1 Question NICE encourages further research on corticosteroid-eluting bioabsorbable stent or spacer insertion

    Research recommendation
    Published
    6 April 2016

  11. NICE encourages further research into endoscopic radiofrequency ablation for Barrett's oesophagus with no dysplasia. Studies should define clearly the policies used for histological diagnosis. Outcomes should include complete resolution of Barrett's oesophagus, change and progression to low-grade dysplasia, high-grade dysplasia or cancer. All complications should be reported, particularly development of strictures. Comparative studies against surveillance would be useful.

    Recommendation ID IPG496/1 Question NICE encourages further research into endoscopic radiofrequency ablation for Barrett's oesophagus with

    Research recommendation
    Published
    9 June 2015

  12. NICE also considered the role of FeNO in guiding inhaled corticosteroid dosing through stepping-up and stepping-down protocols. It accepted there is a need for more evidence on which protocols offer the safest and most optimal asthma management when used in UK clinical practice. Therefore, further studies are recommended, with consideration for the different protocols and cut-off points that may be necessary in different populations.

    Recommendation ID DG12/3 Question NICE also considered the role of FeNO in guiding inhaled corticosteroid dosing through stepping-up and

    Research recommendation
    Published
    9 June 2015

  13. NICE encourages further research into radiofrequency treatment for haemorrhoids, preferably randomised controlled trials. It may update the guidance on publication of further evidence. Outcomes should include pain, secondary haemorrhage, recurrence rate, the need for repeat procedures and quality-of-life measures. Details of patient selection should also be reported.

    Recommendation ID IPG589/1 Question NICE encourages further research into radiofrequency treatment for haemorrhoids, preferably randomised

    Research recommendation
    Published
    15 October 2018

  14. NICE encourages further research into endoscopic radiofrequency ablation for squamous dysplasia of the oesophagus, including observational data collection. Studies should clearly define patient selection. Outcomes should include completeness of ablation, resolution of squamous dysplasia, progression to cancer and quality of life. All complications should be reported, particularly development of oesophageal strictures.

    Recommendation ID IPG497/1 Question NICE encourages further research into endoscopic radiofrequency ablation for squamous dysplasia of

    Research recommendation
    Published
    9 June 2015

  15. NICE encourages further research on endovascular aneurysm sealing for abdominal aortic aneurysmthis procedure in the form of controlled clinical trials, observational studies and analysis of registry data. Details about patient selection, including anatomical details, should be clearly documented.Research should compare the procedure with conventional stent graft endovascular aneurysm repair. All complications should be reported. Long-term outcomes should be described as data become available. NICE may update the guidance on publication of further evidence.

    Recommendation ID IPG547/1 Question NICE encourages further research on endovascular aneurysm sealing for abdominal aortic aneurysmthis

    Research recommendation
    Published
    21 March 2016