Appendix: Search strategy and evidence selection

Appendix: Search strategy and evidence selection

Search strategy

General background, guidelines and technology assessments:

Broad internet search: Google: allintitle: Colesevelam; allintitle: Cholestagel; allintitle: welchol; Colesevelam.pdf; Cholestagel.pdf

Trip Database: Colesevelam; Cholestagel; welchol; lodalis

MEDLINE (via Ovid)

Database: Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) <1946 to Present>

Search Strategy:

  1. Colesevelam.tw. (195)

  2. Cholestagel.tw. (5)

  3. welchol.tw. (16)

  4. lodalis.tw. (0)

  5. "bile acid sequestrant".tw. (236)

  6. or/1-5 (360)

  7. exp Inflammatory Bowel Diseases/ (59129)

  8. Gastrointestinal Transit/ (4178)

  9. Diarrhea/ (39024)

  10. (bile adj3 (malabsorption or absorption)).tw. (994)

  11. (Gastroenteritis or bowel or intestinal or gastrointestinal or diarrh?ea? or crohn$ or colitis or c?eliac).tw. (524995)

  12. "Bile Acids and Salts"/ (19161)

  13. or/7-12 (559666)

  14. 6 and 13 (145)

  15. limit 14 to english language (142)

Embase (via Ovid)

Database: Embase <1988 to 2013 July 17>

Search Strategy:

  1. Colesevelam.tw. (268)

  2. Cholestagel.tw. (37)

  3. welchol.tw. (152)

  4. lodalis.tw. (1)

  5. "bile acid sequestrant".tw. (220)

  6. or/1-5 (511)

  7. exp Inflammatory Bowel Diseases/ (146481)

  8. Gastrointestinal Transit/ (2871)

  9. Diarrhea/ (127289)

  10. (bile adj3 (malabsorption or absorption)).tw. (751)

  11. (Gastroenteritis or bowel or intestinal or gastrointestinal or diarrh?ea? or crohn$ or colitis or c?eliac).tw. (507668)

  12. "Bile Acids and Salts"/ (11506)

  13. or/7-12 (627137)

  14. 6 and 13 (195)

  15. limit 14 to (english language and exclude medline journals) (23)

Cochrane Central Register of Controlled Trials (CENTRAL)

#1 Cholestagel

#2 Colesevelam

#1 or #3

CRD HTA, DARE and EED database

((Colesevelam or cholestagel or welchol or lodalis))

Manufacturers' websites

Daiichi Sankyo, Inc (USA)

Valeant (Canada)

Evidence selection

This evidence summary included all identified published studies that have investigated the efficacy and safety of colesevelam in people with bile acid malabsorption. Results presented only as conference abstracts were excluded.