Advice
Appendix: Search strategy and evidence selection
Search strategy
General background, guidelines and technology assessments
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Broad internet search: Google:
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allintitle: rifaximin pouchitis filetype:pdf
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allintitle: pouchitis treatment filetype:pdf
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Trip Database: Rifaximin pouchitis
MEDLINE (via Ovid)
Database: Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) <1946 to Present> (via Ovid)
Search Strategy:26/11/13
1 exp Rifamycins/ (17967)
2 rifaximin.ti,ab. (595)
3 1 or 2 (18166)
4 Colonic Pouches/ (1125)
5 Pouchitis/ (606)
6 pouchitis.ti,ab. (1114)
7 ileo?anal pouch.ti,ab. (301)
8 4 or 5 or 6 or 7 (2236)
9 3 and 8 (21)
10 limit 9 to english language (21)
Database: Ovid MEDLINE(R) In-Process & Other Non-Indexed
Citations and Ovid MEDLINE(R) <1946 to Present>
Search Strategy:02/12/13
1 exp rifamycins/ (17995)
2 rifaximin.ti,ab. (596)
3 1 or 2 (18194)
4 ileal pouch*.ti,ab. (1824)
5 pouch ileitis.ti,ab. (19)
6 4 or 5 (1833)
7 3 and 6 (7)
8 limit 7 to english language (7)
Embase (via Ovid)
Embase <1988 to 2013 November 26>
Search Strategy:27/11/13
1 exp rifamycin/ (1614)
2 rifaximin.ti,ab. (912)
3 1 or 2 (2434)
4 exp proctocolectomy/ (3625)
5 ileitis/ (3271)
6 pouchitis.ti,ab. (1516)
7 ileo?anal pouch.ti,ab. (378)
8 4 or 5 or 6 or 7 (6636)
9 3 and 8 (32)
10 limit 9 to (english language and exclude medline journals) (4)
Cochrane Central Register of Controlled Trials (CENTRAL) (via Wiley interface)
Search strategy: 27/11/13
#1 MeSH descriptor: [Rifamycins] explode all trees
#2 rifaximin:ti,ab
#3 #1 or #2
#4 MeSH descriptor: [Colonic Pouches] explode all trees
#5 MeSH descriptor: [Pouchitis] explode all trees
#6 pouchitis:ti,ab
#7 ileoanal pouch:ti,ab
#8 ileo-anal pouch:ti,ab
#9 ileo anal pouch:ti,ab
#10 #4 or #5 or #6 or #7 or #8 or #9
#11 #3 and #10
CRD HTA, DARE and EED database (via CRD interface)
Search Strategy: 27/11/13
1 MeSH DESCRIPTOR rifamycins EXPLODE ALL TREES
2 (rifaximin)
3 #1 OR #2
4 MeSH DESCRIPTOR colonic pouches EXPLODE ALL TRE
5 MeSH DESCRIPTOR pouchitis EXPLODE ALL TREES
6 (pouchitis) OR (ileoanal pouch) OR (ileo anal pouch)
7 (ileo-anal pouch)
8 #4 OR #5 OR #6 OR #7
9 #3 AND #8
Evidence selection
The evidence was reviewed with no restriction on patient population studied (including underlying medical indication for ileal pouch-anal anastomosis); indication for rifaximin (including treatment of acute or chronic pouchitis and refractory pouchitis, or as maintenance therapy after remission); dose or duration of rifaximin; use of rifaximin as monotherapy or in combination with other treatments; or comparators. Because of the limited published evidence available, all identified randomised controlled trials and observational studies of rifaximin for the treatment of pouchitis were included. Systematic reviews that did not provide evidence for rifaximin beyond the already identified primary studies were excluded. Conference abstracts were also excluded.