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Carfilzomib with dexamethasone and lenalidomide for previously treated multiple myeloma

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2 Information about carfilzomib

Marketing authorisation indication

2.1 Carfilzomib (Kyprolis, Amgen) is indicated 'in combination with either lenalidomide and dexamethasone or dexamethasone alone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy'.

Dosage in the marketing authorisation

2.2 The dosage schedule is available in the summary of product characteristics.

Price

2.3 The list price of carfilzomib is £1,056 for a 60-mg vial (excluding VAT; BNF online, accessed July 2020). Multiple courses of treatment will be used in combination with lenalidomide and dexamethasone. The company has a commercial arrangement, which would have applied if the technology had been recommended.