Interventional procedure overview of nerve graft for corneal denervation
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Summary of key evidence on autograft: lateral antebrachial cutaneous nerve graft with orbital nerves as donor for corneal denervation
Study 7 Bourcier T (2019)
Study type | Case report |
|---|---|
Country | France |
Recruitment period | Not reported |
Study population and number | n=1 eye in 1 person Adult with neurotropic keratitis caused by chronic herpes simplex viral infection |
Age and sex | 32 years old; male |
Patient selection criteria | Not reported |
Technique | Lateral antebrachial cutaneous nerve graft end-to-end coapted to the contralateral supraorbital nerve. The 4 branches of the graft were sutured to the scleral limbus positions using 10/0 Nylon sutures. |
Follow up | 12 months |
Conflict of interest/source of funding | Conflict of interest: The authors declared no conflicts of interest. Source of funding: funded by Les Hôpitaux Universitaires de Strasbourg, Strasbourg, France. |
Analysis
Study design issues: This case report described the first use of the lateral antebrachial cutaneous nerve for corneal neurotisation in an adult with herpes-related neurotrophic keratitis. Outcomes included corneal sensation, measured by Cochet-Bonnet aesthesiometry, and visual acuity.
Key efficacy findings
Number of people analysed: 1 eye in 1 person
Follow up at time of assessment: Up to 12 months.
- Over 12 months follow up, there was a return of corneal sensation and improvement in BCVA cornea.
Assessment time | Corneal sensation (aesthesiometry) | BCVA |
Before surgery | Absence of sensation | 20/200 |
3 month follow up | 10 to 15 mm | 20/200 |
6 month follow up | Not reported | 20/100 |
12 month follow up | 40 mm | 20/80 |
Abbreviations: BCVA, best-corrected visual acuity.
Key safety findings
Number of people analysed: 1 eye in 1 person
Follow up at time of assessment: Up to 12 months.
Numbness of the left forehead and forearm, n=1
Resolved over 6 months.
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