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Pembrolizumab plus chemotherapy for untreated, triple-negative, locally recurrent unresectable or metastatic breast cancer

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2 Information about pembrolizumab

Marketing authorisation indication

2.1 Pembrolizumab (KEYTRUDA, Merck Sharp & Dohme) has a marketing authorisation for use in combination with chemotherapy 'for the treatment of locally recurrent unresectable or metastatic triple-negative breast cancer in adults whose tumours express PD-L1 with a CPS ≥10 and who have not received prior chemotherapy for metastatic disease'.

Dosage in the marketing authorisation

2.2 The dosage schedule is available in the summary of product characteristics.

Price

2.3 The company's list price is £2,630 per 100 mg solution for infusion vial (excluding VAT, BNF online accessed January 2022).

2.4 The company has a commercial arrangement. This makes pembrolizumab available to the NHS with a discount and it would have also applied to this indication if the technology had been recommended. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.