Interventional procedure overview of trabeculectomy with a biodegradable collagen matrix implant for glaucoma

2 meta-analyses comparing trabeculectomy plus biodegradable collagen implant with trabeculectomy plus antimetabolites were included. There is some overlap of primary studies between the 2 meta-analyses. Studies included were small and heterogenous in terms of design, population, types of glaucoma, duration, and outcomes. The majority of the studies were specific to Egyptian and Asian populations. Only 4 studies were from Europe. The follow-up period ranged from 6 to 60 months. Studies included mainly patients with open-angle glaucoma and few with angle-closure glaucoma but results are not stratified according to the type of glaucoma.

One RCT compared another implant (Express shunt) plus trabeculectomy with biodegradable collagen implant trabeculectomy. Both procedures received surface modification with MMC prior to implant insertion. This study was specific to Asian population and results may not be generalisable.