Percutaneous thrombectomy for massive pulmonary embolism
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3 Committee considerations
The evidence
3.1 NICE did a rapid review of the published literature on the efficacy and safety of this procedure. This comprised a comprehensive literature search and detailed review of the evidence from 5 sources, which was discussed by the committee. The evidence included 2 single-arm trials (1 trial included with its sub-study), 1 safety database review, 1 retrospective comparative study and 1 prospective registry. The evidence is presented in the summary of key evidence section in the interventional procedures overview. Other relevant literature is in the appendix of the overview.
3.2 The professional experts and the committee considered the key efficacy outcomes to be: clot removal, recovery of cardiac function, 30‑day mortality or survival, symptomatic relief, long-term patient-reported outcome measures, and quality of life.
3.3 The professional experts and the committee considered the key safety outcomes to be: pain, bleeding, damage to vessels and the heart, and worsening cardiac function.
Committee comments
3.4 The committee noted that more than 1 device can be used for this procedure. Devices vary in the size of the introducer and their mechanism and are at different stages of development.
Tom Clutton-Brock
Chair, interventional procedures advisory committee
March 2023
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