Interventional procedure overview of percutaneous thrombectomy for massive pulmonary embolism
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Methods
NICE identified studies and reviews relevant to percutaneous thrombectomy for massive and submassive pulmonary embolus from the medical literature. The following databases were searched between the date they started to 18th August 2022: MEDLINE, PREMEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the internet were also searched (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.
The following inclusion criteria were applied to the abstracts identified by the literature search.
Publication type: clinical studies were included with emphasis on identifying good quality studies. Abstracts were excluded if they did not report clinical outcomes. Reviews, editorials, and laboratory or animal studies, were also excluded and so were conference abstracts, because of the difficulty of appraising study methodology, unless they reported specific adverse events that not available in the published literature.
Patients with massive and submassive pulmonary embolism.
Intervention or test: percutaneous mechanical thrombectomy
Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy, or both.
If selection criteria could not be determined from the abstracts the full paper was retrieved.
Potentially relevant studies not included in the main evidence summary are listed in the section on other relevant studies.
Find out more about how NICE selects the evidence for the committee.
Databases | Date searched | Version/files |
MEDLINE (Ovid) | 19/08/2022 | 1946 to August 18, 2022 |
MEDLINE In-Process (Ovid) | 19/08/2022 | 1946 to August 18, 2022 |
MEDLINE Epubs ahead of print (Ovid) | 19/08/2022 | August 18, 2022 |
EMBASE (Ovid) | 19/08/2022 | 1974 to 2022 August 18 |
EMBASE Conference (Ovid) | 19/08/2022 | 1974 to 2022 August 18 |
Cochrane Database of Systematic Reviews – CDSR (Cochrane Library) | 19/08/2022 | Issue 8 of 12, August 2022 |
Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library) | 19/08/2022 | Issue 7 of 12, July 2022 |
International HTA database (INAHTA) | 19/08/2022 | - |
Trial sources searched
Clinicaltrials.gov
ISRCTN
WHO International Clinical Trials Registry
Websites searched
National Institute for Health and Care Excellence (NICE)
NHS England
Food and Drug Administration (FDA) - MAUDE database
Australian Safety and Efficacy Register of New Interventional Procedures – Surgical (ASERNIP – S)
Australia and New Zealand Horizon Scanning Network (ANZHSN)
General internet search
The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.
The MEDLINE search strategy was translated for use in the other sources.
1 Thrombectomy/ 9486
2 percutaneous.tw. 139833
3 1 and 2 1184
4 (percutaneous adj4 thrombectom*).tw. 564
5 3 or 4 1279
6 catheter*.tw. 198862
7 Catheters/ 6814
8 (mechanical* adj4 thrombectom*).tw. 3581
9 or/6-8 203262
10 5 and 9 636
11 Venous Thromboembolism/ 14419
12 ((Venous adj4 (thrombo-embolism* or thromboembolism*)) or VTE).ti,ab. 23485
13 Pulmonary Embolism/ 42217
14 (((Pulmonary or lung*) adj4 embol*) or PE).ti,ab. 83515
15 Venous Thrombosis/ 28631
16 (((vein* or ven*) adj4 thromb*) or DVT).ti,ab. 83500
17 (thrombus* or thrombotic* or thrombolic* or thromboemboli* or thrombos* or embol*).ti,ab. 331968
18 (blood adj4 clot*).ti,ab. 11774
19 or/11-18 397581
20 10 and 19 554
21 EKOS.tw. 72
22 21 and 19 63
23 (Indigo adj4 Aspiration).tw. 19
24 FlowTriever*.tw. 29
25 AlphaVac.tw. 0
26 or/20,22-25 652
27 Animals/ not Humans/ 5004253
28 26 not 27 638
29 limit 28 to english language 596
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