Interventional procedure overview of cryotherapy for chronic rhinitis
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Existing assessments of this procedure
The Triological Society reviewed the evidence to seek answering whether in-office PNN ablation is an effective treatment for the symptoms of AR (Davies 2022). Based on 4 single-arm prospective cohort studies (level 3) and 1 RCT (level 2), it was recommended that "although the number of randomised controlled trials (RCTs) is lacking, given the consistency of earlier prospective single-arm cohort studies, combined with the support of newer well-designed RCTs, there is enough evidence to support PNN as an effective treatment for allergic rhinitis symptoms, particularly nasal congestion, and rhinorrhoea. Given the favourable side effect profile of in-office PNN, there appears to be a role for cryoablation or radiofrequency neurolysis in treating symptoms of AR. Future studies should confirm these findings with additional RCTs using sham control procedures, longer follow-up, and larger and more diverse patient populations."
The Japanese guidelines for allergic rhinitis 2020 (Okubo 2020) described an evidence-based step-by-step strategy for treatment. Operative treatment for AR was recommended as appropriate, such as cryosurgery and laser surgery.
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