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    Methods

    NICE identified studies and reviews relevant to vaginal transluminal endoscopic hysterectomy and adnexal surgery for benign gynaecological conditions from the medical literature. The following databases were searched between the date they started to 22 November 2022: MEDLINE, PREMEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the internet were also searched (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.

    The following inclusion criteria were applied to the abstracts identified by the literature search.

    • Publication type: clinical studies were included with emphasis on identifying good quality studies. Abstracts were excluded if they did not report clinical outcomes. Reviews, editorials, and laboratory or animal studies, were also excluded and so were conference abstracts, because of the difficulty of appraising study methodology, unless they reported specific adverse events that not available in the published literature.

    • Patients with benign gynaecological conditions.

    • Intervention or test: vaginal natural orifice transluminal endoscopic surgery (vNOTES).

    • Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy, or both.

    If selection criteria could not be determined from the abstracts the full paper was retrieved.

    Potentially relevant studies not included in the main evidence summary are listed in the section on other relevant studies.

    Find out more about how NICE selects the evidence for the committee.

    Table 4 literature search strategy

    Databases

    Date searched

    Version/files

    MEDLINE (Ovid)

    22/11/2022

    1946 to November 07, 2022

    MEDLINE In-Process (Ovid)

    22/11/2022

    1946 to November 07, 2022

    MEDLINE Epubs ahead of print (Ovid)

    22/11/2022

    1946 to November 07, 2022

    EMBASE (Ovid)

    22/11/2022

    1974 to 2022 November 07

    EMBASE Conference (Ovid)

    22/11/2022

    1974 to 2022 November 07

    Cochrane Database of Systematic Reviews – CDSR (Cochrane Library)

    22/11/2022

    Issue 11 of 12, November 2022

    Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library)

    22/11/2022

    Issue 10 of 12, October 2022

    International HTA database (INAHTA)

    22/11/2022

    -

    The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.

    MEDLINE search strategy

    1 exp hysterectomy/ or exp vaginal hysterectomy/ 82,798

    2 ovariectomy/ 39,874

    3 salpingectomy/ 5,840

    4 salpingooophorectomy/ 17,545

    5 (Hysterectom* or ovariect* or salping*).tw. 108,064

    6 (Adnex* adj4 disease*).tw. 595

    7 adnexectom*.tw. 1,803

    8 exp adnexa disease/ 263,667

    9 ((uter* or womb* or ovar* or (fallop* adj tube*)) adj4 (remov* or excis* or cut* or prolapse*)).tw. 13,193

    10 or/1-9 398,588

    11 natural orifice transluminal endoscopic surgery/ 2,985

    12 (NOTES or vNOTES or VAHN or TVHN or VAMIS).tw. 67,232

    13 ((vagin* or transvagin* or translumin*) adj4 (NOTES or endosc* surg*)).tw. 2,052

    14 (Natur* adj4 Orific* adj4 Endoscop* adj4 Surg*).tw. 2,414

    15 or/11-14 68,569

    16 10 and 15 1,431

    17 GelPOINT-V-PATH.tw,dv,dm. 8

    18 16 or 17 1,433

    19 Nonhuman/ not Human/ 5,072,852

    20 18 not 19 1,408

    21 (conference abstract* or conference review or conference paper or conference proceeding).db,pt,su. 5,346,653

    22 20 not 21 700

    23 20 and 21 708