Irreversible electroporation for treating prostate cancer
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3 Committee considerations
The evidence
3.1 NICE did a rapid review of the published literature on the efficacy and safety of this procedure. This comprised a comprehensive literature search and detailed review of the evidence from 7 sources, which was discussed by the committee. The evidence included 1 systematic review, 1 non-randomised comparative study and 5 case series. It is presented in the summary of key evidence section in the interventional procedures overview. Other relevant literature is in the appendix of the overview.
3.2 The professional experts and the committee considered the key efficacy outcomes to be: overall survival, recurrence-free survival, metastasis-free survival, improvement in quality of life, and need for subsequent intervention.
3.3 The professional experts and the committee considered the key safety outcomes to be: pain, bleeding, infection, loss of sexual function, damage to adjacent structures, incontinence, urethral stricture and recurrence.
Committee comments
3.4 The committee noted that detection, investigation, and management of prostate cancer now involves an increased use of MRI scanning and the published evidence does not reflect this change in practice.
3.5 The committee was pleased to receive a large number of patient commentaries and a submission from a patient organisation, and this supported the need for further research.
3.6 The committee was informed that using MRI ultrasound fusion imaging may be of value in this procedure.
Tom Clutton-Brock
Chair, interventional procedures advisory committee
August 2022
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