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    Interventional procedure overview of irreversible electroporation for treating prostate cancer

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    Validity and generalisability of the studies

    • Most of the studies are case series with relatively short term follow up (6-12 months), and high loss to follow up past this point which severely limits the long-term data.

    • Most of the studies included used data from patients in a single centre in Australia; it is possible that that there is some overlap in the patient populations in these studies in addition to the overlaps explicitly indicated in the overview.

    • The included studies analysed populations with differing severity of prostate cancer.

    • Detection, investigation, and management of prostate cancer now involves an increased use of MRI and the included studies do not reflect this change in practice.