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    Literature search strategy

    Databases

    Date searched

    Version/files

    Cochrane Database of Systematic Reviews – CDSR (Cochrane Library)

    22/12/2021

    Issue 12 of 12, December 2021

    Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library)

    22/12/2021

    Issue 12 of 12, December 2021

    International HTA database

    22/12/2021

    -

    MEDLINE (Ovid)

    22/12/2021

    1946 to December 21, 2021

    MEDLINE In-Process (Ovid) & MEDLINE ePubs ahead of print (Ovid)

    22/12/2021

    December 21, 2021

    EMBASE (Ovid)

    22/12/2021

    1974 to 2021 December 21

    Embase Conference (Ovid)

    22/12/2021

    1974 to 2021 December 21

    Trial sources searched

    • Clinicaltrials.gov

    • ISRCTN

    • WHO International Clinical Trials Registry

    Websites searched

    • National Institute for Health and Care Excellence (NICE)

    • NHS England

    • Food and Drug Administration (FDA) - MAUDE database

    • Australian Safety and Efficacy Register of New Interventional Procedures – Surgical (ASERNIP – S)

    • Australia and New Zealand Horizon Scanning Network (ANZHSN)

    • General internet search

    The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.

    Literature search strategy

    Number

    Search term

    1

    Eye diseases/ or Vision Disorders/

    2

    Vitreous Body/

    3

    1 and 2

    4

    (vitre* adj4 (opacit* or degenerat* or disorder* or disease* or disab* or impair* or abnormal* or disturb*)).tw.

    5

    (floater* or musca* volitan*).tw.

    6

    Vitreous Detachment/

    7

    (vitre* detach* or PVD).tw.

    8

    (Weiss* ring* or Martegiani* ring*).tw.

    9

    or/3-8

    10

    Laser Therapy/ or Lasers, Solid-State/ or Lasers/

    11

    (YAG* or Neodymium-YAG* or Nd:YAG* or Nd-YAG* or yttrium alumin?um garnet).tw.

    12

    (laser* adj4 (therap* or surg* or treatment* or procedur* or operat* or cut* or non-thermal* or pulse* or solid-state* or q-switched or ablat* or photoablat* or knife or knives or scalpel*)).tw.

    13

    (vapori* or vapouri*).tw.

    14

    Vitreolysis.tw.

    15

    or/10-14

    16

    Tango Reflex*.tw.

    17

    Ultra Q Reflex*.tw.

    18

    16 or 17

    19

    9 and 15

    20

    18 or 19

    21

    animals/ not humans/

    22

    20 not 21