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    The content on this page is not current guidance and is only for the purposes of the consultation process.

    Validity and generalisability of the studies

    • When reported, studies were done in various countries and data relating to the UK context (Bonavina 2020) were included

    • There was 1 RCT (low risk of bias) which compared laparoscopic MSA with PPIs.

    • When comparing laparoscopic insertion of a magnetic ring with fundoplication, Zhuang (2021) included Nissen fundoplication, and Guidozzi (2019), Aiolfi (2018) and Bonavina (2020) included both total and partial fundoplication.

    • The longest follow up was a median of 9 years (Ferrari 2020). Two studies reported outcomes at 5 years or more (Zhuang 2021; DeMarchi 2021) and the remaining studies reported outcomes between 6 and 50 months.

    • There was variation in the population included, such as hiatal hernia size, GORD severity, oesophagitis severity, and presence of Barrett's oesophagus. There was some patient overlap between the studies.

    • There was variation in the procedural technique depending on the presence of hiatal hernia, the size of the hiatal defect, and the degree of hiatus hernia.

    • Device has evolved over time and different generations of the LINX Reflux Management System were used.

    • Length of hospital stay might be affected by different healthcare systems, such as in Germany, patients had longer stay built into reimbursement as shown in Bonavina (2020).