Interventional procedure overview of selective internal radiation therapy for neuroendocrine tumours that have metastasised to the liver
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Methods
NICE identified studies and reviews relevant to selective internal radiation therapy from the medical literature. The following databases were searched between the date they started to 31st May 2023: MEDLINE, PREMEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the internet were also searched (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.
The following inclusion criteria were applied to the abstracts identified by the literature search.
Publication type: clinical studies were included with emphasis on identifying good quality studies. Abstracts were excluded if they did not report clinical outcomes. Reviews, editorials, and laboratory or animal studies, were also excluded and so were conference abstracts, because of the difficulty of appraising study methodology.
Patients with neuroendocrine tumours metastatic to the liver.
Intervention or test: selective internal radiation therapy.
Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy, or both.
If selection criteria could not be determined from the abstracts the full paper was retrieved.
Potentially relevant studies not included in the main evidence summary are listed in the section on other relevant studies.
Find out more about how NICE selects the evidence for the committee.
Databases | Date searched | Version/files |
|---|---|---|
MEDLINE (Ovid) | 01/06/2023 | 1946 to May 31 2023 |
MEDLINE In-Process (Ovid) | 01/06/2023 | 1946 to May 31 2023 |
MEDLINE Epubs ahead of print (Ovid) | 01/06/2023 | May 31 2023 |
EMBASE (Ovid) | 01/06/2023 | 1974 to 2023 May 31 |
Cochrane Database of Systematic Reviews – CDSR (Cochrane Library) | 01/06/2023 | 6 of 12 June 2023 |
Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library) | 01/06/2023 | 6 of 12 June 2023 |
International HTA database (INAHTA) | 01/06/2023 |
The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.
Ovid MEDLINE(R) <1946 to May 31, 2023>
1 neuroendocrine tumors/ and exp liver/ 170
2 (neuroendocrine adj4 (tumo* or neoplas* or carcinoma* or cancer* or metast*) adj4 (liver or hepat*)).tw. 1224
3 ((net or mnet) adj4 (liver or hepat* or metast*)).tw. 1433
4 nelm.tw. 64
5 exp Carcinoid Tumor/ and exp liver/ 147
6 (carcinoid adj4 (tumo* or syndrome*) adj4 (liver or hepat*)).tw. 359
7 or/1-6 3048
8 ("selective internal radiotherap*" or "selective internal radiation therap*" or "select internal radiotherap*" or sirt).tw. 1758
9 Embolization, Therapeutic/ 36312
10 (radioembolization or radioembolisation or radioembolotherap* or tare).tw. 1763
11 (intraarterial brachytherapy or intra arterial brachytherapy).tw. 11
12 exp yttrium/ 7469
13 (yttrium 90 or y90 or 90y).tw. 3652
14 Holmium/ 1133
15 (holmium 166 or 166Ho).tw. 189
16 Microspheres/ 30637
17 (bead* or microbead* or sphere* or microsphere* or particle*).tw. 377224
18 or/8-17 426227
19 7 and 18 270
20 (sir sphere or therasphere or quiremsphere*).tw. 76
21 19 or 20 342
22 animal/ not human/ 5091102
23 21 not 22 328
24 limit 23 to english language/ 307
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