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    Methods

    NICE identified studies and reviews relevant to transfemoral carotid artery stent placement for asymptomatic extracranial carotid stenosis from the medical literature. The following databases were searched between 2011 to 28/02/2023: MEDLINE, PREMEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the internet were also searched (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.

    The following inclusion criteria were applied to the abstracts identified by the literature search.

    • Publication type: clinical studies were included with emphasis on identifying good quality studies. Abstracts were excluded if they did not report clinical outcomes. Reviews, editorials, and laboratory or animal studies, were also excluded and so were conference abstracts, because of the difficulty of appraising study methodology, unless they reported specific adverse events that not available in the published literature. Because of the size of the evidence base, a separate broad search was done to identify randomised controlled trials and systematic reviews.

    • Patients with asymptomatic carotid stenosis.

    • Intervention or test: transfemoral carotid artery stent placement.

    • Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy, or both.

    If selection criteria could not be determined from the abstracts the full paper was retrieved.

    Potentially relevant studies not included in the main evidence summary are listed in the section on other relevant studies.

    Find out more about how NICE selects the evidence for the committee.

    Table 4 literature search strategy

    Two sets of searches were conducted – a precise search for all study designs and a more sensitive version that was limited by study design.

    Databases

    Date searched

    Version/files

    MEDLINE (Ovid)

    19/12/2022

    1946 to 2022 December 16

    MEDLINE In-Process (Ovid)

    19/12/2022

    1946 to 2022 December 16

    MEDLINE Epubs ahead of print (Ovid)

    19/12/2022

    December 16 022

    EMBASE (Ovid)

    19/12/2022

    1974 to 2022 December 16

    EMBASE Conference (Ovid)

    19/12/2022

    1974 to 2022 December 16

    Cochrane Database of Systematic Reviews – CDSR (Cochrane Library)

    19/12/2022

    Issue 12 of 12, December 2022

    Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library)

    19/12/2022

    Issue 11 of 12, November 2022

    International HTA database (INAHTA)

    19/12/2022

    -

    The following search strategies were used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.

    Precise search – not limited by study design

    Medline search strategy

    1 carotid artery diseases/ or carotid stenosis/

    2 (Carotid* adj4 Arter* adj4 (diseas* or obstruct* or occlu* or obliterat* or disorder* or narrow* or plaque* or block* or stricture* or constrict*)).tw.

    3 (Carotid* adj4 (ulcer* or stenos*)).tw.

    4 (Carotid* adj4 (atherosclero* or athero-sclero* or arterioscler* or arterio-scler* or arteriopath*)).tw.

    5 or/1-4

    6 angioplasty, balloon/ or Angioplasty/

    7 Dilatation/

    8 Catheters/ or Catheterization/

    9 (Balloon* adj4 (dilat* or cathet* or expand* or inflat* or angioplast*)).tw.

    10 (Transluminal adj4 arter* adj4 dilat*).tw.

    11 (endoluminal adj4 repair*).tw.

    12 (carotid adj4 arter* adj4 (angioplast* or endovascular* or catheter* or cannul*)).tw.

    13 or/6-12

    14 exp carotid arteries/

    15 stents/ or self expandable metallic stents/ or Blood Vessel Prosthesis Implantation/

    16 14 and 15

    17 (Carotid adj4 stent* adj4 (place* or tech* or implant* or device* or prosthe*)).tw.

    18 (CAS adj4 (place* or tech* or implant* or device* or prosthe*)).tw.

    19 or/16-18

    20 13 and 19

    21 5 and 20

    22 ((Acculink or X?act or enroute or Roadsaver or Casper or MER or Cristallo Ideale or CGuard or SINUS Carotid RX or Precise or Exponent or Protege RX) adj2 stent*).tw.

    23 (NexStent or WALLSTENT).tw.

    24 22 or 23

    25 5 and 24

    26 21 or 25

    27 Animals/ not humans/

    28 26 not 27

    29 limit 28 to english language

    Broader search limited by study design

    Databases

    Date searched

    Version/files

    MEDLINE (Ovid)

    28/02/2023

    1946 to February 27, 2023

    MEDLINE In-Process (Ovid)

    28/02/2023

    1946 to February 27, 2023

    MEDLINE Epubs ahead of print (Ovid)

    28/02/2023

    February 27, 2023

    EMBASE (Ovid)

    28/02/2023

    1974 to February 27, 2023

    EMBASE Conference (Ovid)

    28/02/2023

    1974 to February 27, 2023

    Cochrane Database of Systematic Reviews – CDSR (Cochrane Library)

    28/02/2023

    Issue 2 of 12, February 2023

    Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library)

    28/02/2023

    Issue 2 of 12, February 2023

    International HTA database (INAHTA)

    28/02/2023

    -

    1        carotid artery diseases/ or carotid stenosis/

    2        (Carotid* adj4 Arter* adj4 (diseas* or obstruct* or occlu* or obliterat* or disorder* or narrow* or plaque* or block* or stricture* or constrict*)).tw.

    3        (Carotid* adj4 (ulcer* or stenos*)).tw.

    4        (Carotid* adj4 (atherosclero* or athero-sclero* or arterioscler* or arterio-scler* or arteriopath*)).tw.

    5        or/1-4

    6        exp carotid arteries/

    7        stents/ or self expandable metallic stents/ or Blood Vessel Prosthesis Implantation/

    8        6 and 7

    9        (Carotid adj4 stent*).tw.

    10        (CAS adj4 (place* or tech* or implant* or device* or prosthe*)).tw.

    11        or/8-10

    12        ((Acculink or X?act or enroute or Roadsaver or Casper or MER or Cristallo Ideale or CGuard or SINUS Carotid RX or Precise or Exponent or Protege RX) adj2 stent*).tw.

    13        (NexStent or WALLSTENT).tw.

    14        or/11-13

    15        5 and 14

    16        Animals/ not humans/