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2 Information about setmelanotide

Marketing authorisation indication

2.1 Setmelanotide (Imcivree, Rhythm Pharmaceuticals) is indicated for 'the treatment of obesity and the control of hunger associated with genetically confirmed Bardet-Biedl syndrome (BBS)…in adults and children 6 years of age and above.'

Dosage in the marketing authorisation

2.2 The dosage schedule is available in the summary of product characteristics.

Price

2.3 The list price of setmelanotide is £2,376.00 per 10 mg/ml vial for injection (excluding VAT; BNF online, accessed July 2023).

2.4 The company has a commercial arrangement. This makes setmelanotide available to the NHS with a discount and it would have also applied to this indication if the technology had been recommended. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.