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  • Question on Consultation

    Are there any aspects of the recommendations that need particular consideration to ensure we avoid unlawful discrimination against any group of people on the grounds of race, gender, disability, religion or belief, sexual orientation, age, gender reassignment, pregnancy and maternity?

  • Question on Consultation

    Has all of the relevant evidence been taken into account?

  • Question on Consultation

    Are the summaries of clinical and and cost effectiveness reasonable interpretations of the evidence?

  • Question on Consultation

    Are the recommendations sound and a suitable basis for guidance to the NHS?
The content on this page is not current guidance and is only for the purposes of the consultation process.

1 Recommendations

Closed for comments This consultation ended on at   Request commenting lead permission

2 Information about dupilumab

Marketing authorisation indication

2.1 Dupilumab (Dupixent, Sanofi) is indicated for 'the treatment of adults with moderate-to-severe prurigo nodularis (PN) who are candidates for systemic therapy'.

Dosage in the marketing authorisation

2.2 The dosage schedule is available in the summary of product characteristics for dupilumab.

Price

2.3 The list price of dupilumab is £1,264.89 for a 2‑pack of 300 mg per 2 ml solution for injection pre-filled syringes or pens (excluding VAT; BNF online accessed August 2023).

2.4 The company has a commercial arrangement. This makes dupilumab available to the NHS with a discount and it would have also applied to this indication if the technology had been recommended. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.