Endoscopic duodenal mucosal resurfacing for insulin resistance in type 2 diabetes

NICE did a rapid review of the published literature on the efficacy and safety of this procedure. This comprised a comprehensive literature search and detailed review of the evidence from 5 sources, which was discussed by the committee. The evidence included 1 randomised controlled trial, 2 prospective cohort studies (1 study with 2 publications) and 1 proof of concept study. It is presented in the summary of key evidence section in the interventional procedures overview. Other relevant literature is in the appendix of the overview.

The professional experts and the committee considered the key efficacy outcomes to be: quality of life, improved blood sugar control and reduced use of antidiabetic medication, in particular insulin.

The professional experts and the committee considered the key safety outcomes to be: perforation, duodenal stenosis and gastrointestinal symptoms.

Patient commentary was sought but none was received.

The committee was informed that this procedure:

Registry data may be helpful in determining the safety and long-term efficacy of the procedure.