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2 Information about trastuzumab deruxtecan

Marketing authorisation indication

2.1 Trastuzumab deruxtecan (Enhertu, Daiichi Sankyo) is indicated for 'the treatment of adult patients with unresectable or metastatic HER2-low breast cancer who have received prior chemotherapy in the metastatic setting or developed disease recurrence during or within 6 months of completing adjuvant chemotherapy'.

Dosage in the marketing authorisation

2.2 The dosage schedule is available in the summary of product characteristics for trastuzumab deruxtecan.

Price

2.3 The list price of trastuzumab deruxtecan is £1,455 per 1 vial containing 100 mg powder for concentrate for solution for infusion (excluding VAT; BNF online accessed September 2023).

2.4 The company has a commercial arrangement. This makes trastuzumab deruxtecan available to the NHS with a discount and it would have also applied to this indication if the technology had been recommended. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.