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2 Information about setmelanotide

Marketing authorisation indication

2.1

Setmelanotide (Imcivree, Rhythm Pharmaceuticals) is indicated for 'the treatment of obesity and the control of hunger associated with genetically confirmed Bardet-Biedl syndrome (BBS), loss-of-function biallelic pro-opiomelanocortin (POMC), including PCSK1, deficiency or biallelic leptin receptor (LEPR) deficiency in adults and children 6 years of age and above'.

Price

2.3

The list price of setmelanotide is £2,376.00 per 10 mg/ml vial for injection (excluding VAT; BNF online, accessed July 2023).

2.4

The company has a commercial arrangement (simple patient access scheme). This makes setmelanotide available to the NHS with a discount. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.