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2 Information about ivosidenib with azacitidine

Marketing authorisation indication

2.1

Ivosidenib (Tibsovo, Servier Laboratories) in combination with azacitidine is indicated for 'the treatment of adult patients with newly diagnosed acute myeloid leukaemia (AML) with an isocitrate dehydrogenase-1 (IDH1) R132 mutation who are not eligible to receive standard induction chemotherapy'.

Price

2.3

The list price of a 60‑tablet pack of 250 mg ivosidenib is £12,500, or £150,000 for a year of treatment (excluding VAT; BNF online accessed January 2024). At the time of evaluation, the average price of azacitidine was £45.16 per 100 mg vial (eMIT accessed September 2023).

2.4

The company has a commercial arrangement. This makes ivosidenib available to the NHS with a discount and it would have also applied to this indication if the technology had been recommended. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.