Interventional procedure overview of transcatheter aortic valve implantation for native aortic valve regurgitation
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Appendix A: Methods and literature search strategy
NICE has identified studies and reviews relevant to transcatheter aortic valve implantation for native aortic valve regurgitation from the medical literature.
1 Search strategy design and peer review
This search report is informed by the Preferred Reporting Items for Systematic reviews and Meta-Analyses literature search extension (PRISMA-S).
A NICE information specialist ran the literature searches on 09/08/2024 and updated them on [date]. See the search strategy history for the full search strategy for each database. Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.
The principal search strategy was developed in MEDLINE ALL (Ovid interface). It was adapted for use in each of the databases listed in table 4a, taking into account the database's size, search functionality and subject coverage. The MEDLINE ALL strategy was quality assured by a NICE senior information specialist. All translated search strategies were peer reviewed to ensure their accuracy. The quality assurance and peer review procedures were adapted from the Peer Review of Electronic Search Strategies (PRESS) 2015 evidence-based checklist.
2 Review management
The search results were managed in EPPI‑Reviewer version 5 (EPPI‑R5). Duplicates were removed in EPPI‑R5 using a 2‑step process. First, automated deduplication was done using a high-value algorithm. Second, manual deduplication was used to assess low-probability matches. All decisions about inclusion, exclusion and deduplication were recorded and stored.
3 Limits and restrictions
The CENTRAL database search removed trial registry records and conference material. The Embase search excluded conference material.
English language limits were applied to the search when possible in the database due to the volume of results.
The limit to remove animal studies in the searches is standard NICE practice, which has been adapted from Dickersin K, Scherer R, Lefebvre C (1994) Systematic Reviews: Identifying relevant studies for systematic reviews. BMJ 309(6964): 1286.
4 Main search
Database | Date searched | Database platform | Database segment or version | Number of results downloaded |
|---|---|---|---|---|
Cochrane Central Register of Controlled Trials (CENTRAL) | 09/08/2024 | Wiley | Issue 7 of 12, July 2024 | 121 |
Cochrane Database of Systematic Reviews (CDSR) | 09/08/2024 | Wiley | Issue 8 of 12, August 2024 | 3 Reviews 1 Protocol |
Embase | 09/08/2024 | Ovid | 1974 to 2024 August 08 | 3345 |
INAHTA International HTA Database | 09/08/2024 | https://database.inahta.org/ | - | 16 |
MEDLINE ALL | 09/08/2024 | Ovid | 1946 to 2024 August 08 | 2253 |
Search strategy history
MEDLINE ALL search strategy
1 Transcatheter Aortic Valve Replacement/ 12187
2 ((Transcatheter or Transapical or transventricular) adj4 (Aortic or "heart valve") adj4 (Replacement* or transplant* or implant* or prosthes*)).tw. 16125
3 (PAVR or TAVI or TAVR).ti,ab. 12434
4 or/1-3 19632
5 Aortic Valve Insufficiency/ 16282
6 (Aortic adj4 (Insufficienc* or Regurgitation or incompetence or degeneration)).tw. 17007
7 (AR or NPAR).ti,ab. 66009
8 or/5-7 88364
9 4 and 8 2276
10 animals/ not humans/ 5212304
11 9 not 10 2252
12 J-Valve.tw. 56
13 CoreValve.tw. 1236
14 "ACURATE neo".tw. 173
15 "Sapien 3".tw. 852
16 Lotus.tw. 4675
17 or/12-16 6779
18 8 and 17 565
19 11 or 18 2312
20 limit 19 to english language 2252
Embase search strategy
1 transcatheter aortic valve implantation/ 35141
2 ((Transcatheter or Transapical or transventricular) adj4 (Aortic or "heart valve") adj4 (Replacement* or transplant* or implant* or prosthes*)).tw. 27802
3 (PAVR or TAVI or TAVR).ti,ab. 25722
4 or/1-3 39674
5 aortic regurgitation/ 13817
6 (Aortic adj4 (Insufficienc* or Regurgitation or incompetence or degeneration)).tw. 25302
7 (AR or NPAR).ti,ab. 89890
8 5 or 6 or 7 118058
9 4 and 8 5634
10 Nonhuman/ not Human/ 5506959
11 9 not 10 5578
12 J-Valve.tw,dv,dm. 128
13 CoreValve.tw,dv,dm. 5830
14 "ACURATE neo".tw,dv,dm. 543
15 "Sapien 3".tw,dv,dm. 3474
16 Lotus.tw,dv,dm. 5750
17 or/12-16 13725
18 8 and 17 2118
19 11 or 18 5688
20 limit 19 to english language 5583
21 (conference abstract* or conference review or conference paper or conference proceeding).db,pt,su. 5997612
22 20 not 21 3344
Cochrane Library (CDSR and CENTRAL) search strategy
Search Hits
#1 MeSH descriptor: [Transcatheter Aortic Valve Replacement] this term only 495
#2 ((Transcatheter or Transapical or transventricular) NEAR/4 (Aortic or "heart valve") NEAR/4 (Replacement* or transplant* or implant* or prosthes*)) 1331
#3 PAVR or TAVI or TAVR 1237
#4 #1 or #2 or #3 1471
#5 MeSH descriptor: [Aortic Valve Insufficiency] this term only 197
#6 Aortic NEAR/4 (Insufficienc* or Regurgitation or incompetence or degeneration) 616
#7 (AR or NPAR) 20782
#8 {OR #5-#7} 21321
#9 #4 AND #8 188
#10 J-Valve 4
#11 CoreValve 173
#12 "ACURATE neo" 19
#13 "Sapien 3" 117
#14 Lotus 225
#15 {OR #10-#14} 480
#16 #8 AND #15 86
#17 #9 or #16 199
#18 "conference":pt or (clinicaltrials or trialsearch):so 770307
#19 #17 NOT #18 in Cochrane Reviews, Cochrane Protocols 4
#20 #17 NOT #18 in Trials 121
INAHTA HTA Database search strategy
Line Query Hits
1 (Transcatheter Aortic Valve Replacement)[mh] 34
2 ((Transcatheter or Transapical or transventricular) AND (Aortic or "heart valve") AND (Replacement* or transplant* or implant* or prosthes*)) 62
3 PAVR or TAVI or TAVR 58
4 #3 OR #2 OR #1 74
5 (Aortic Valve Insufficiency)[mh] 5
6 (Aortic AND (Insufficienc* or Regurgitation or incompetence or degeneration)) 14
7 (AR or NPAR) 0
8 #7 OR #6 OR #5 19
9 #8 AND #4 12
10 J-Valve 186
11 CoreValve 5
12 "ACURATE neo" 0
13 "Sapien 3" 0
14 Lotus 0
15 #14 OR #13 OR #12 OR #11 OR #10 186
16 #15 AND #8 16
Inclusion criteria
The following inclusion criteria were applied to the abstracts identified by the literature search.
Publication type: clinical studies were included with emphasis on identifying good quality studies. Abstracts were excluded if they did not report clinical outcomes. Reviews, editorials, and laboratory or animal studies, were also excluded and so were conference abstracts, because of the difficulty of appraising study methodology, unless they reported specific adverse events not available in the published literature.
People with aortic regurgitation or aortic incompetence.
Intervention or test: Transcatheter aortic valve implantation.
Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy, or both.
If selection criteria could not be determined from the abstracts the full paper was retrieved.
Potentially relevant studies not included in the main evidence summary are listed in Appendix B: Other relevant studies.
Find out more about how NICE selects the evidence for the committee.
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