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The condition and experiences of people with it

3.1

Metastatic colorectal cancer (mCRC) is an adenocarcinoma of the colon or rectum that has spread beyond the large intestine, most often to the liver, lung or peritoneum. The patient experts explained that colorectal cancer is also associated with poor long-term survival rates unless people are diagnosed and have treatment at earlier stages of the condition. They also noted that the ability to diagnose and treat as early as possible may vary across NHS trusts. This can result in a postcode lottery for access to services that would prevent progression to metastatic disease. Both the patient and clinical experts outlined the significant impact on quality of life and severity of the side effects associated with existing mCRC treatment options. They also noted the difficulty in balancing treatment effectiveness with toxicity. The committee agreed that there is an unmet clinical need for treatments with better outcomes for people with mCRC, who would welcome new treatment options.