Interventional procedure overview of MRI-guided focused ultrasound thalamotomy for treating moderate to severe tremor in Parkinson's
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Methods
NICE identified studies and reviews relevant to MRI-guided focused ultrasound thalamotomy for moderate to severe tremor in Parkinson's from the medical literature. The following databases were searched between the date they started to 23 January 2024: MEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the internet were also searched (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.
The following inclusion criteria were applied to the abstracts identified by the literature search.
Publication type: clinical studies were included with emphasis on identifying good quality studies. Abstracts were excluded if they did not report clinical outcomes. Reviews, editorials, and laboratory or animal studies, were also excluded and so were conference abstracts, because of the difficulty of appraising study methodology, unless they reported specific adverse events that not available in the published literature.
Patients with Parkinson's and tremor.
Intervention or test: MRgFUS thalamotomy.
Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy, or both.
If selection criteria could not be determined from the abstracts the full paper was retrieved.
Potentially relevant studies not included in the main evidence summary are listed in the section on other relevant studies.
Find out more about how NICE selects the evidence for the committee.
Databases | Date searched | Version/files |
|---|---|---|
MEDLINE ALL (Ovid) | 23/01/2024 | 1946 to January 22, 2024 |
EMBASE (Ovid) | 23/01/2024 | 1974 to January 22 2024 |
Cochrane Database of Systematic Reviews – CDSR (Cochrane Library) | 23/01/2024 | Issue 1 of 12, January 2024 |
Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library) | 23/01/2024 | Issue 1 of 12 January 2024 |
International HTA database (INAHTA) | 23/01/2024 | - |
The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.
2 Parkinsonian Disorders/ 9451
3 PD.tw. 193005
4 parkinson*.tw. 147490
5 Tremor/ or Essential Tremor/ 13254
6 Tremor*.tw. 26936
7 Movement Disorders/ 16990
8 ((movement* or motor) adj4 (disord* or diseas* or dysfunct*)).tw. 57655
9 (shaking palsy or shaking palsies).tw. 83
10 (Paralysis adj4 agitans).tw. 204
11 or/1-10 355249
12 Magnetic Resonance Imaging/ 482375
13 Magnetic Resonance Imaging, Interventional/ 1871
14 MRI.tw. 317937
15 ((MR or magnet*) adj4 (guid* or imag* or resonanc*)).tw. 470159
16 or/12-15 800244
17 exp Ultrasonic Therapy/ 14094
18 Ultrasonography, Interventional/ 28603
19 High-Intensity Focused Ultrasound Ablation/ 2254
20 ((ultraso* or ultra-so*) adj4 (therap* or surg* or ablat* or thalamotom*)).tw. 17476
21 ((High-intensity or focus*) adj4 (ultraso* or ultra-so* or thalamotom*)).tw. 10839
22 (focus* adj4 acoustic* adj4 energy*).tw. 65
23 (ultrasonograph* adj4 intervention*).tw. 463
24 HIFU.tw. 3007
25 thermoablat*.tw. 542
26 (therm* adj4 ablat*).tw. 5970
27 or/17-26 66218
28 11 and 16 and 27 457
29 (MRgFUS or MRgHIFU).tw. 711
30 28 or 29 969
31 exablate.tw. 69
32 30 or 31 992
33 animals/ not humans/ 5155377
34 32 not 33 897
35 limit 34 to ed=20230118-20240131 73
36 limit 34 to dt=20230118-20240131 102
37 35 or 36 116
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