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  • Question on Consultation

    Has all of the relevant evidence been taken into account?

  • Question on Consultation

    Are the summaries of clinical and cost effectiveness reasonable interpretations of the evidence?

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    Are the recommendations sound and a suitable basis for guidance to the NHS?

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    Are there any aspects of the recommendations that need particular consideration to ensure we avoid unlawful discrimination against any group of people on the grounds of age, disability, gender reassignment, pregnancy and maternity, race, religion or belief, sex or sexual orientation?
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1 Recommendations

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2 Information about pembrolizumab

Marketing authorisation indication

2.1

Pembrolizumab (Keytruda, MSD), in combination with carboplatin and paclitaxel, is indicated for 'the first-line treatment of primary advanced or recurrent endometrial carcinoma in adults'.

Price

2.3

The list price is £2,630.00 for a 25 mg per 1 ml concentrate for solution for infusion 4-ml vial (excluding VAT; BNF online accessed February 2025).

2.4

The company has a commercial arrangement. This makes pembrolizumab available to the NHS with a discount and it would have also applied to this indication if pembrolizumab with carboplatin and paclitaxel had been recommended. The size of the discount is commercial in confidence.

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