3.1
The evidence for Senza considered by the external assessment centre (EAC) comprised 10 studies in adults with chronic neuropathic pain. Of these 10, 3 studies (Al-Kaisy et al. 2017b, De Andres et al. 2017 and Van Buyten et al. 2017) became available during consultation on the original draft recommendations, and 1 became available (Amirdelfan et al. 2018) after a further consultation on the second draft recommendations. The 10 studies were:
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2 randomised controlled trials comparing Senza and low‑frequency spinal cord stimulation (SCS; Kapural et al. 2015 and 2016 and De Andres et al. 2017)
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1 before-and-after study (Tiede et al. 2013)
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5 single-arm observational studies (Al-Kaisy et al. 2014, Russo et al. 2016, Rapcan et al. 2015, Al-Kaisy et al. 2017a and Al-Kaisy et al. 2017b)
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1 retrospective chart review (Van Buyten et al. 2017)
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1 quality-of-life analysis using data from Kapural et al. 2016 (Amirdelfan et al. 2018).
Full details of all the evidence are in the project documents on the NICE website.