Guidance
Recommendations for research
Recommendations for research
The guideline committee has made the following key recommendations for research.
Key recommendations for research
1 Auto- and fixed-level CPAP for managing mild OSAHS
What is the clinical and cost effectiveness of auto- and fixed-level continuous positive airway pressure (CPAP) for managing mild obstructive sleep apnoea/hypopnoea syndrome (OSAHS)?
For a short explanation of why the committee made the recommendation for research, see the rationale section on treatments for mild OSAHS.
Full details of the evidence and the committee's discussion are in evidence review F: positive airway pressure therapy variants for OSAHS, OHS and COPD–OSAHS overlap syndrome.
2 Auto- and fixed-level CPAP for managing moderate and severe OSAHS
What is the clinical and cost effectiveness of auto- and fixed-level continuous positive airway pressure (CPAP) for managing moderate and severe OSAHS?
For a short explanation of why the committee made the recommendation for research, see the rationale section on treatments for moderate and severe OSAHS.
Full details of the evidence and the committee's discussion are in evidence review F: positive airway pressure therapy variants for OSAHS, OHS and COPD–OSAHS overlap syndrome.
3 Interventions to improve CPAP adherence
Which interventions, including behavioural interventions, are most clinically and cost effective to improve adherence to CPAP in people with OSAHS, obesity hypoventilation syndrome (OHS) and COPD–OSAHS (chronic obstructive pulmonary disease–OSAHS) overlap syndrome who have difficulty using CPAP?
For a short explanation of why the committee made the recommendation for research, see the rationale section on supporting adherence to treatment for OSAHS.
Full details of the evidence and the committee's discussion are in evidence review N: adherence.
4 Mandibular advancement splints for mild symptomatic OSAHS
In mild symptomatic OSAHS, which clinical and physiological phenotypes predict treatment response to customised mandibular advancement splints?
For a short explanation of why the committee made the recommendation for research, see the rationale section on treatments for mild OSAHS.
Full details of the evidence and the committee's discussion are in evidence review G: oral devices.
5 Mandibular advancement splints for moderate OSAHS
In moderate OSAHS, which clinical and physiological phenotypes predict treatment response to customised mandibular advancement splints?
For a short explanation of why the committee made the recommendation for research, see the rationale section on treatments for moderate and severe OSAHS.
Full details of the evidence and the committee's discussion are in evidence review G: oral devices.
6 Mandibular advancement splints for severe OSAHS
What is the clinical and cost effectiveness of mandibular advancement splints for managing severe OSAHS?
For a short explanation of why the committee made the recommendation for research, see the rationale section on treatments for moderate and severe OSAHS.
Full details of the evidence and the committee's discussion are in evidence review G: oral devices.
7 Treatment for people with COPD–OSAHS overlap syndrome
What is the optimal treatment for people with COPD–OSAHS overlap syndrome: non-invasive ventilation or CPAP?
For a short explanation of why the committee made the recommendation for research, see the rationale section on treatments for COPD–OSAHS overlap syndrome.
Full details of the evidence and the committee's discussion are in evidence review F: positive airway pressure therapy variants for OSAHS, OHS and COPD–OSAHS overlap syndrome.
Other recommendations for research
8 Upper airway surgery in people unable to tolerate or adhere to CPAP
What is the clinical and cost effectiveness of upper airway surgical interventions for people with OSAHS who are unable to tolerate or adhere to CPAP?
For a short explanation of why the committee made the recommendation for research, see the rationale section on surgery for OSAHS.
Full details of the evidence and the committee's discussion are in evidence review J: surgery.
9 Oxygen therapy for OSAHS
What is the clinical and cost effectiveness of nocturnal oxygen compared with placebo in people with OSAHS who are unable to tolerate CPAP?
For a short explanation of why the committee made this recommendation for research and how it might affect practice, see the rationale section on oxygen therapy for OSAHS.
Full details of the evidence and the committee's discussion are in evidence review I: oxygen therapy.