6.1
The committee considered the heterogeneity and uncertainty in the studies. The committee heard from the clinical specialists on the committee that histopathology practices can vary between hospitals in the UK. It also heard that, in routine clinical practice, the standard of histopathology may be different to that in the studies. It concluded that the extensive research-standard histopathology described in the studies may not be representative of the histopathology conducted in routine clinical NHS practice because it is very time consuming. The committee also concluded that there is variation in how histopathology is performed across the NHS.