3.1
Metreleptin (Myalepta, Amryt) is an analogue of the human hormone leptin, which is secreted into the circulation from adipocytes. Metreleptin has a UK marketing authorisation under 'exceptional circumstances' as 'an adjunct to diet as a replacement therapy to treat the complications of leptin deficiency in lipodystrophy (LD) patients:
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with confirmed congenital generalised LD (Berardinelli–Seip syndrome) or acquired generalised LD (Lawrence syndrome) in adults and children 2 years of age and above
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with confirmed familial partial LD or acquired partial LD (Barraquer–Simons syndrome), in adults and children 12 years of age and above for whom standard treatments have failed to achieve adequate metabolic control'.