Documents A list of downloadable documents created during development. Final appraisal determination Final appraisal determination Final appraisal determination document PDF 335 KB 12 May 2017 Public committee slides PDF 897 KB 12 May 2017 Public committee slides PDF 447 KB 12 May 2017 Committee papers PDF 15.49 MB 12 May 2017 Invitation to participate Final matrix PDF 101 KB 02 June 2016 Final protocol PDF 351 KB 27 June 2016 Final scope PDF 112 KB 18 August 2016 NICE's response to comments on the draft scope and provisional matrix PDF 134 KB 18 August 2016 Draft scope documents Draft scope (post-referral) PDF 147 KB 29 February 2016 Provisional matrix (post-referral) PDF 100 KB 29 February 2016