Status In progress
Technology type Medicine
Decision Selected
Reason for decision Anticipate the topic will be of importance to patients, carers, professionals, commissioners and the health of the public to ensure clinical benefit is realised, inequalities in use addressed, and help them make the best use of NHS resources
Further information Scoping
Process MTA Standard
ID number 6369

Provisional Schedule

Committee meeting: 1 05 February 2025
Expected publication 16 July 2025

Project Team

Project lead Vonda Murray

Email enquiries

External Assessment Group Bristol Technology Assessment Group, University of Bristol

Stakeholders

Companies sponsors Biogen (natalizumab)
  Sandoz (Tyruko (natalizumab biosimilar))
Others Department of Health and Social Care
  Health Technology Wales (HTW)
  NHS England
  Welsh Government
Patient carer groups Multiple Sclerosis Society
  Multiple Sclerosis Trust
Professional groups Association of British Neurologists
  Royal College of Physicians
Associated public health groups Public Health Wales
  UK Health Security Agency
Comparator companies Janssen-Cilag (ponesimod) (confidentiality agreement signed, participating)
  Merck Serono (cladribine, interferon beta-1a) (confidentiality agreement signed, participating)
  Novartis Pharmaceuticals (fingolimod, interferon beta-1a, interferon beta-1b, ofatumumab) (confidentiality agreement signed, participating)
  Amarox (fingolimod) (confidentiality agreement not signed, not participating)
  Bayer (interferon beta-1a, interferon beta-1b) (confidentiality agreement not signed, not participating)
  Biocon Pharma (fingolimod) (confidentiality agreement not signed, not participating)
  Biogen Idec (interferon beta-1a) (confidentiality agreement not signed, not participating)
  Dr. Reddy's Laboratories (fingolimod) (confidentiality agreement not signed, not participating)
  Glenmark Pharmaceuticals (fingolimod) (confidentiality agreement not signed, not participating)
  Mylan (fingolimod, glatiramer acetate, teriflunomide) (confidentiality agreement not signed, not participating)
  Roche Products (ocrelizumab) (confidentiality agreement not signed, not participating)
  Sandoz (fingolimod) (confidentiality agreement not signed, not participating)
  Sanofi Genzyme (alemtuzumab) (confidentiality agreement not signed, not participating)
  Sun Pharma (fingolimod) (confidentiality agreement not signed, not participating)
  Teva (fingolimod, glatiramer acetate) (confidentiality agreement not signed, not participating)
  Tillomed Laboratories (fingolimod) (confidentiality agreement not signed, not participating)
  Zenvita (fingolimod) (confidentiality agreement not signed, not participating)
General commentators All Wales Therapeutics and Toxicology Centre
  British National Formulary
  Department of Health - Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  Welsh Health Specialised Services Committee
Relevant research groups Brain Research UK
  Cochrane Multiple Sclerosis and Rare Diseases of the Central Nervous System Group
  Cochrane UK
  Genomics England
  MRC Clinical Trials Unit

Timeline

Key events during the development of the guidance:

Date Update
04 December 2024 Assessment report sent for information
03 May 2024 Invitation to participate
19 January 2024 - 16 February 2024 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators
19 January 2024 In progress

For further information on our processes and methods, please see our CHTE processes and methods manual