Suggested remit: To appraise the clinical and cost effectiveness of amivantamab in combination with carboplatin and pemetrexed within its marketing authorisation for untreated EGFR exon 20 insertion mutation-positive advanced non-small-cell lung cancer.
 
Status In progress
Technology type Medicine
Decision Selected
Reason for decision Anticipate the topic will be of importance to patients, carers, professionals, commissioners and the health of the public to ensure clinical benefit is realised, inequalities in use addressed, and help them make the best use of NHS resources
Process STA Standard
ID number 5110

Provisional Schedule

Committee meeting 12 February 2025
Expected publication 30 April 2025

Project Team

Project lead Greg O'Toole

Email enquiries

External Assessment Group Kleijnen Systematic Reviews Ltd

Stakeholders

Companies sponsors Johnson and Johnson (amivantamab)
Others Department of Health and Social Care
  NHS England
Patient carer groups EGFR Positive UK
  Roy Castle Lung Cancer Foundation
Professional groups Association of Cancer Physicians
  British Thoracic Oncology Group
  Cancer Research UK
  Royal College of Physicians
  Royal College of Radiologists
Associated public health groups None
Comparator companies Amarox (erlotinib) (confidentiality agreement not signed, not participating)
  Aspire pharma (pemetrexed) (confidentiality agreement not signed, not participating)
  AstraZeneca (gefitinib, osimertinib) (confidentiality agreement signed, participating)
  Boehringer Ingelheim (afatinib) (confidentiality agreement not signed, not participating)
  Bristol Myers Squibb (paclitaxel) (confidentiality agreement not signed, not participating)
  Cipla EU (gefitinib) (confidentiality agreement not signed, not participating)
  Eli Lilly and company (pemetrexed) (confidentiality agreement not signed, not participating)
  Genus pharmaceuticals (pemetrexed, gefitinib) (confidentiality agreement not signed, not participating)
  Glenmark Pharmaceutical (erlotinib) (confidentiality agreement not signed, not participating)
  Hospira UK (carboplatin, cisplatin, docetaxel, gemcitabine, paclitaxel) (confidentiality agreement not signed, not participating)
  Medac GmbH (vinorelbine) (confidentiality agreement not signed, not participating)
  Merck, Sharp & Dohme (pembrolizumab) (confidentiality agreement signed, participating)
  Mylan (erlotinib) (confidentiality agreement not signed, not participating)
  Pfizer (pemetrexed, dacomitinib) (confidentiality agreement signed, participating)
  Pierre Fabre (vinorelbine) (confidentiality agreement not signed, not participating)
  Roche (atezolizumab, erlotinib) (confidentiality agreement signed, participating)
  Sandoz (cisplatin, docetaxel, pemetrexed, erlotinib, gefitinib) (confidentiality agreement not signed, not participating)
  Seacross pharmaceuticals (docetaxel, paclitaxel, pemetrexed) (confidentiality agreement not signed, not participating)
  Sun Pharmaceuticals (gemcitabine, pemetrexed) (confidentiality agreement not signed, not participating)
  Synchrony Pharma (gemcitabine) (confidentiality agreement not signed, not participating)
  Teva UK (paclitaxel) (confidentiality agreement not signed, not participating)
  Zentiva (pemetrexed, erlotinib) (confidentiality agreement not signed, not participating)
General commentators All Wales Therapeutics and Toxicology Centre
  British National Formulary
  Department of Health – Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  Scottish Medicines Consortium
  Welsh Government
  Welsh Health Specialised Services Committee
Relevant research groups Institute of Cancer Research

Timeline

Key events during the development of the guidance:

Date Update
10 July 2024 Invitation to participate
23 May 2024 - 21 June 2024 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators: 5110
23 May 2024 In progress. Scoping commenced.
30 November 2023 Please note that following on from advice received from the company this appraisal has been rescheduled. We now anticipate that the appraisal will begin during mid-July 2024 when we will write to you about how you can get involved. The deadline for submissions is expected in approximately mid-September 2024.
04 May 2022 Awaiting development. Status change linked to Topic Selection Decision being set to Selected
14 April 2022 Awaiting development. Status change linked to Topic Selection Decision being set to Selected
14 April 2022 Topic selection

For further information on our processes and methods, please see our CHTE processes and methods manual