Suggested remit: To appraise the clinical and cost effectiveness of acalabrutinib with bendamustine and rituximab within its marketing authorisation for untreated mantle cell lymphoma.
 
Status In progress
Technology type Medicine
Decision Selected
Reason for decision Anticipate the topic will be of importance to patients, carers, professionals, commissioners and the health of the public to ensure clinical benefit is realised, inequalities in use addressed, and help them make the best use of NHS resources
Process STA Standard
ID number 6155

Provisional Schedule

Committee meeting 11 June 2025
Expected publication 20 August 2025

Project Team

Project lead Leena Issa

Email enquiries

External Assessment Group Health Economics Research Unit and Health Services Research Unit, University of Aberdeen

Stakeholders

Companies sponsors AstraZeneca
Others Department of Health and Social Care
  NHS England
Patient carer groups Lymphoma Action
Professional groups Association of Cancer Physicians
  Cancer Research UK
  Royal College of Pathologists
  Royal College of Physicians
  Royal College of Radiologists
Associated public health groups None
Comparator companies Accord-UK Ltd (bendamustine) – confidentiality agreement not signed, not participating
  Aspire Pharma (bortezomib) – confidentiality agreement not signed, not participating
  Aurobindo Pharma (bortezomib) – confidentiality agreement not signed, not participating
  Baxter Healthcare Ltd (cyclophosphamide, doxorubicin) – confidentiality agreement not signed, not participating
  Biotech Pharma (bortezomib) – confidentiality agreement not signed, not participating
  Celltrion Healthcare UK Ltd (rituximab) – confidentiality agreement not signed, not participating
  Dr Reddy’s Laboratories UK Ltd (bendamustine, bortezomib) – confidentiality agreement not signed, not participating
  Hospira UK Ltd (cytarabine, vincristine) – confidentiality agreement not signed, not participating
  Jazz Pharmaceuticals UK (cytarabine) – confidentiality agreement not signed, not participating
  Johnson & Johnson Ltd (bortezomib) – confidentiality agreement not signed, not participating
  medac GmbH (bortezomib, doxorubicin) – confidentiality agreement not signed, not participating
  MSN Laboratories Europe (bortezomib) – confidentiality agreement not signed, not participating
  Mylan (bortezomib) – confidentiality agreement not signed, not participating
  Pfizer Ltd (bortezomib, doxorubicin, rituximab) – confidentiality agreement not signed, not participating
  Roche Products Ltd (rituximab) – confidentiality agreement not signed, not participating
  Sandoz Ltd (bortezomib, cyclophosphamide, rituximab) – confidentiality agreement not signed, not participating
  Seacross Pharmaceuticals Ltd (bendamustine, doxorubicin) – confidentiality agreement not signed, not participating
  Sun Pharma (bortezomib) – confidentiality agreement not signed, not participating
  Thornton & Ross Ltd (bortezomib) – confidentiality agreement not signed, not participating
  Tillomed Laboratories Ltd (bortezomib) – confidentiality agreement not signed, not participating
  Zentiva Pharma Ltd (bendamustine) – confidentiality agreement not signed, not participating
General commentators All Wales Therapeutics and Toxicology Centre
  British National Formulary
  Department of Health - Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  NHS Wales Joint Commissioning Committee
  Scottish Medicines Consortium
  Welsh Government
Relevant research groups Institute of Cancer Research

Timeline

Key events during the development of the guidance:

Date Update
24 September 2024 Invitation to participate
23 July 2024 - 20 August 2024 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators: 6155
23 July 2024 In progress. Scoping commenced.
25 April 2023 As you will be aware, the Department for Health & Social Care has asked NICE to conduct an appraisal of Acalabrutinib with bendamustine and rituximab within its marketing authorisation for untreated mantle cell lymphoma [ID6155]. Please note that following on from advice received from the company this appraisal will be rescheduled to align with latest regulatory expectations.
11 July 2022 Awaiting development. Status change linked to Topic Selection Decision being set to Selected

For further information on our processes and methods, please see our CHTE processes and methods manual