Suggested remit: To appraise the clinical and cost effectiveness of belantamab mafodotin with bortezomib and dexamethasone within its marketing authorisation for treating relapsed or refractory multiple myeloma after 1 or more treatments.
 
Status In progress
Technology type Medicine
Decision Selected
Reason for decision Anticipate the topic will be of importance to patients, carers, professionals, commissioners and the health of the public to ensure clinical benefit is realised, inequalities in use addressed, and help them make the best use of NHS resources
Process STA Standard
ID number 6212

Provisional Schedule

Committee meeting: 1 08 January 2025
Expected publication 05 March 2025

Project Team

Project lead Vonda Murray

Email enquiries

External Assessment Group Centre for Reviews and Dissemination and Centre for Health Economics, University of York

Stakeholders

Companies sponsors GlaxoSmithKline (belantamab mafodotin)
Others Department of Health and Social Care
  Health Technology Wales
  NHS England
Patient carer groups Myeloma UK
Professional groups Association of Cancer Physicians
  Cancer Research UK
  Royal College of Physicians
  Royal College of Radiologists
  UK Myeloma Society
Assessment group Centre for Reviews and Dissemination and Centre for Health Economics, University of York
Associated public health groups None
Comparator companies AbbVie (dexamethasone) (confidentiality agreement signed, participating)
  Bristol Myers Squibb Pharmaceuticals (lenalidomide, pomalidomide) (confidentiality agreement signed, participating)
  Menarini Stemline UK (selinexor) (confidentiality agreement signed, participating)
  Takeda UK (ixazomib) (confidentiality agreement signed, participating)
  ADVANZ Pharma (dexamethasone, lenalidomide) (confidentiality agreement not signed, not participating)
  Amarox (lenalidomide) (confidentiality agreement not signed, not participating)
  Amgen (carfilzomib) (confidentiality agreement not signed, not participating)
  AS Kalceks (dexamethasone) (confidentiality agreement not signed, not participating)
  Aspen (dexamethasone) (confidentiality agreement not signed, not participating)
  Aspire Pharma (bortezomib, dexamethasone) (confidentiality agreement not signed, not participating)
  Aurobindo Pharma (bortezomib) (confidentiality agreement not signed, not participating)
  Bausch & Lomb U.K (dexamethasone) (confidentiality agreement not signed, not participating)
  Biocon Pharma UK (lenalidomide) (dexamethasone) (confidentiality agreement not signed, not participating)
  Dr. Reddy's Laboratories UK (bortezomib) (dexamethasone) (confidentiality agreement not signed, not participating)
  Glenmark Pharmaceuticals Europe (dexamethasone, lenalidomide) (dexamethasone) (confidentiality agreement not signed, not participating)
  Hameln pharma (dexamethasone) (dexamethasone) (confidentiality agreement not signed, not participating)
  Hospira UK (dexamethasone) (dexamethasone) (confidentiality agreement not signed, not participating)
  Janssen-Cilag (bortezomib, daratumumabl) (dexamethasone) (confidentiality agreement not signed, not participating)
  Krka UK (dexamethasone) (confidentiality agreement not signed, not participating)
  Martindale Pharma, an Ethypharm Group Company (dexamethasone) (confidentiality agreement not signed, not participating)
  Medac GmbH (bortezomib) (confidentiality agreement not signed, not participating)
  MSN Laboratories Europe (bortezomib) (confidentiality agreement not signed, not participating)
  Mylan (bortezomib, lenalidomide) (confidentiality agreement not signed, not participating)
  Novartis Pharmaceuticals UK (dexamethasone) (confidentiality agreement not signed, not participating)
  Panpharma UK (dexamethasone) (confidentiality agreement not signed, not participating)
  ParaPharm Development (dexamethasone) (confidentiality agreement not signed, not participating)
  Pfizer (bortezomib, elranatamab) (confidentiality agreement not signed, not participating)
  Piramal Critical Care (lenalidomide) (confidentiality agreement not signed, not participating)
  Ranbaxy UK Limited a Sun (confidentiality agreement not signed, not participating)
  Pharmaceutical Company (bortezomib, lenalidomide) (confidentiality agreement not signed, not participating)
  Rayner Pharmaceuticals (dexamethasone) (confidentiality agreement not signed, not participating)
  Rosemont Pharmaceuticals (dexamethasone) (confidentiality agreement not signed, not participating)
  Sandoz (bortezomib, lenalidomide) (confidentiality agreement not signed, not participating)
  Sanofi (dexamethasone, isatuximab) (confidentiality agreement not signed, not participating)
  Santen UK (dexamethasone) (confidentiality agreement not signed, not participating)
  Synchrony Pharma (dexamethasone) (confidentiality agreement not signed, not participating)
  Teva UK (dexamethasone, lenalidomide) (confidentiality agreement not signed, not participating)
  Thame Laboratories (dexamethasone) (confidentiality agreement not signed, not participating)
  Thea Pharmaceuticals (dexamethasone) (confidentiality agreement not signed, not participating)
  Thornton & Ross (bortezomib, lenalidomide) (confidentiality agreement not signed, not participating)
  Tillomed Laboratories (bortezomib) (confidentiality agreement not signed, not participating)
  Wockhardt UK (dexamethasone) (confidentiality agreement not signed, not participating)
  Zentiva (bortezomib, lenalidomide) (confidentiality agreement not signed, not participating)
  ZR Pharma & GmBH (panobinostat) (confidentiality agreement not signed, not participating)
General commentators All Wales Therapeutics and Toxicology Centre
  British National Formulary
  Department of Health, Social Services and Public Safety for Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  Scottish Medicines Consortium
  Welsh Government
  Welsh Health Specialised Services Committee
Relevant research groups None

Timeline

Key events during the development of the guidance:

Date Update
11 March 2024 Invitation to participate
15 January 2024 - 12 February 2024 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators: 6212
31 July 2023 Please note that following on from a request received from the company, the timelines for this appraisal have been revised and the appraisal is now anticipated to begin in mid-March 2024. These timings are based on a request from the company to reschedule the initial date set by NICE, in order to facilitate a suitably comprehensive and robust submission.
14 March 2023 In progress. DHSC referral received
23 November 2022 Awaiting development. Status change linked to Topic Selection Decision being set to Selected

For further information on our processes and methods, please see our CHTE processes and methods manual