Suggested remit: To appraise the clinical and cost effectiveness of cabozantinib within its marketing authorisation for treating advanced pancreatic or extra-pancreatic neuroendocrine tumours that have progressed after systemic treatment.
 
Status In progress
Technology type Medicine
Decision Selected
Reason for decision Anticipate the topic will be of importance to patients, carers, professionals, commissioners and the health of the public to ensure clinical benefit is realised, inequalities in use addressed, and help them make the best use of NHS resources
Process STA Standard
ID number 6474

Provisional Schedule

Committee meeting 10 September 2025
Expected publication 19 November 2025

Project Team

Project lead Greg O'Toole

Email enquiries

External Assessment Group BMJ Technology Assessment Group (BMJ-TAG), BMJ

Stakeholders

Companies sponsors Ipsen (cabozantinib)
Others Department of Health and Social Care
  NHS England
Patient carer groups Bowel Cancer UK
  Neuroendocrine Cancer UK
Professional groups Association of Cancer Physicians
  Cancer Research UK
  Royal College of Physicians
  Society for Endocrinology
  UKI NETS
Associated public health groups None
Comparator companies Accord Healthcare (5-fluorouracil, temozolomide) (confidentiality agreement not signed, not participating)
  Amarox (capecitabine) (confidentiality agreement not signed, not participating)
  Baxter (doxorubicin) (confidentiality agreement not signed, not participating)
  Dr Reddy’s Laboratories (capecitabine, everolimus, sunitinib) (confidentiality agreement not signed, not participating)
  Esteve Pharmaceuticals (streptozocin) (confidentiality agreement not signed, not participating)
  Ethypharm UK (everolimus) (confidentiality agreement not signed, not participating)
  Glenmark Pharmaceuticals (capecitabine) (confidentiality agreement not signed, not participating)
  Hospira UK (carboplatin, cisplatin, 5-fluorouracil) (confidentiality agreement not signed, not participating)
  medac GmBH (doxorubicin, 5-fluorouracil,) (confidentiality agreement not signed, not participating)
  Merck Sharp & Dohme (temozolomide) (confidentiality agreement not signed, not participating)
  MSN Laboratories (sunitinib) (confidentiality agreement not signed, not participating)
  Mylan (sunitinib) (confidentiality agreement not signed, not participating)
  Neon Healthcare (etoposide) (confidentiality agreement not signed, not participating)
  Novartis (everolimus, lutetium (177Lu) oxodotreotide) (confidentiality agreement not signed, not participating)
  Pfizer (doxorubicin, sunitinib) (confidentiality agreement not signed, not participating)
  Piramal Critical Care (sunitinib) (confidentiality agreement not signed, not participating)
  Sandoz (cisplatin, everolimus, sunitinib) (confidentiality agreement not signed, not participating)
  Seacross (doxorubicin) (confidentiality agreement not signed, not participating)
  Sun Pharma (temozolomide) (confidentiality agreement not signed, not participating)
  Teva Pharma (sunitinib) (confidentiality agreement not signed, not participating)
  Zentiva (sunitinib) (confidentiality agreement not signed, not participating)
General commentators All Wales Therapeutics and Toxicology Centre
  British National Formulary
  Department of Health, Social Services and Public Safety for Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  NHS Wales Joint Commissioning Committee
  Scottish Medicines Consortium
  Welsh Government
Relevant research groups None

Timeline

Key events during the development of the guidance:

Date Update
11 February 2025 Invitation to participate
14 November 2024 - 12 December 2024 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators: 6474
12 December 2024 Referral
14 November 2024 In progress. Scoping commencing
20 August 2024 Awaiting development. Status change linked to Topic Selection Decision being set to Selected

For further information on our processes and methods, please see our CHTE processes and methods manual