Tirzepatide for managing overweight and obesity

Orlistat

NICE recommends orlistat as an option for weight management and it can be prescribed in all settings, including primary care, if people meet the criteria in table 1.

Orlistat is taken orally and may be preferable to some people who prefer not to self-inject and are willing to accept the potential adverse effects associated with this medicine.

Orlistat should be prescribed according to the summary of product characteristics for orlistat. Important aspects of prescribing orlistat are summarised in the NICE Clinical Knowledge Summary (CKS) obesity prescribing information.

Liraglutide

NICE recommends liraglutide as an option for weight management and it can be prescribed in secondary care by a specialist overweight and obesity management service, if people meet the criteria in table 1. See NICE's technology appraisal guidance on liraglutide for managing overweight and obesity for more information.

Semaglutide

NICE recommends semaglutide as an option for weight management and it can be prescribed in a specialist overweight and obesity management service, if people meet the criteria in table 1. See NICE's technology appraisal guidance on semaglutide for managing overweight and obesity for more information.