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Lisocabtagene maraleucel for treating relapsed or refractory large B-cell lymphoma after first-line chemoimmunotherapy when a stem cell transplant is suitable

Technology appraisal guidance
Reference number: TA1048
Published: 26 March 2025

Download guidance (PDF)

2 Information about lisocabtagene maraleucel

Marketing authorisation indication

2.1

Lisocabtagene maraleucel (liso‑cel; Breyanzi, Bristol-Myers Squibb) is indicated for 'the treatment of adult patients with diffuse large B‑cell lymphoma (DLBCL), high grade B‑cell lymphoma (HGBCL), primary mediastinal large B‑cell lymphoma (PMBCL) and follicular lymphoma grade 3B (FL3B), who relapsed within 12 months from completion of, or are refractory to, first-line chemoimmunotherapy'.

Dosage in the marketing authorisation

2.2

The dosage schedule is available in the summary of product characteristics for liso-cel.

Price

2.3

The list price for a single infusion, including shipping, engineering and generation of CAR‑T cells is £297,000 (company submission, May 2024).

2.4

The company has a commercial arrangement. This makes liso-cel available to the NHS with a discount. The size of the discount is commercial in confidence.