Routine antenatal anti-D prophylaxis for women who are rhesus D negative

  • Technology appraisal guidance
  • TA156
  • Published: 
Download guidance (PDF)

8 Sources of evidence considered by the Committee

The assessment report for this appraisal was prepared by the University of Sheffield, School of Health and Related Research (ScHARR)

  • Pilgrim H, Lloyd-Jones M, Rees A. Routine antenatal anti-D prophylaxis for RhD-negative women (review), November 2007.

The following organisations accepted the invitation to participate in this appraisal. They were invited to comment on the draft scope, assessment report and the appraisal consultation document (ACD). Manufacturers, or sponsors, professional or specialist and patient or carer groups and other organisations were also invited to make written submissions and have the opportunity to appeal against the final appraisal determination.

Manufacturers or sponsors:

  • Baxter BioScience (Partobulin SDF, WinRho SDF)

  • Bio Products Laboratory (D-Gam)

  • CSL Behring (Rhophylac)

Professional or specialist and patient or carer groups:

  • The Miscarriage Association

  • The National Childbirth Trust (NCT)

  • Association of Radical Midwives

  • NHS Blood and Transplant

  • Royal College of General Practitioners

  • Royal College of Midwives

  • Royal College of Nursing

  • Royal College of Obstetricians and Gynaecologists

  • Royal College of Paediatrics and Child Health

  • Royal College of Pathologists

  • Royal College of Physicians

Other organisations:

  • Bexley Care Trust PCT

  • Department of Health

  • Nottingham City PCT

  • Welsh Assembly Government

Commentator organisations (without the right of appeal):

  • Department of Health, Social Services and Public Safety for Northern Ireland

  • NHS Quality Improvement Scotland

  • School of Health and Related Research, University of Sheffield

  • National Coordinating Centre for Health Technology Assessment

The following individuals were selected from clinical specialist and patient advocate nominations from the non-manufacturer or sponsor consultees and commentators. They participated in the Appraisal Committee discussions and provided evidence to inform the Appraisal Committee's deliberations. They gave their expert personal view on RAADP for women who are RhD negative by attending the initial Committee discussion and/or providing written evidence to the Committee. They were also invited to comment on the ACD.

  • Dr Ann Benton, Consultant Haematologist, nominated by the Royal Colleges of Pathologists and Physicians – clinical specialist

  • Dr Alan Cameron, Consultant Obstetrician, nominated by NHS Quality Improvement Scotland (QIS) – clinical specialist

  • Mrs Emma Wightman, Osteopath and NCT Antenatal Teacher Trainee, nominated by the NCT – patient expert