2.1
Oral alitretinoin (Toctino, Basilea Pharmaceuticals) is indicated for use in adults who have severe chronic hand eczema that is unresponsive to treatment with potent topical corticosteroids. 'Severe' chronic hand eczema (that is, marked signs of eczema, or oedema, fissures or functional impairment) is defined using the physician's global assessment (PGA; see section 3.2).