Alitretinoin for the treatment of severe chronic hand eczema

  • Technology appraisal guidance
  • TA177
  • Published: 
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8 Sources of evidence considered by the Committee

A. The Evidence Review Group (ERG) report for this appraisal was prepared by the Centre for Reviews and Dissemination (CRD), University of York:

  • Paulden M, Rodgers M, Griffin S et al. Alitretinoin for the treatment of severe chronic hand eczema, March 2009

B. The following organisations accepted the invitation to participate in this appraisal as consultees and commentators. They were invited to comment on the draft scope, the ERG report and the appraisal consultation document (ACD). Organisations listed in I were also invited to make written submissions. Organisations listed in II, III and IV had the opportunity to give their expert views. Organisations listed in I, II and III also have the opportunity to appeal against the final appraisal determination.

I) Manufacturer/sponsor:

  • Basilea Pharmaceuticals

II) Professional/specialist and patient/carer groups:

  • British Association of Dermatologists

  • British Contact Dermatitis Society

  • Royal College of Nursing

  • Royal College of Physicians

  • Skin Care Campaign

III) Other consultees:

  • Department of Health

  • Welsh Assembly Government

IV) Commentator organisations (did not provide written evidence and without the right of appeal):

  • British National Formulary

  • Cochrane Skin Group, Centre of Evidence-based Dermatology, University of Nottingham

  • Department of Health, Social Services and Public Safety for Northern Ireland

  • NHS Quality Improvement Scotland

C. The following individuals were selected from clinical specialist and patient expert nominations from the non-manufacturer/sponsor consultees and commentators. They gave their expert personal view on alitretinoin by attending the initial Committee discussion and providing written evidence to the Committee. They were also invited to comment on the ACD.

  • Dr Graham Johnston, Consultant Dermatologist, Leicester Royal Infirmary, nominated by the British Association of Dermatologists – clinical specialist

  • Dr Anthony Ormerod, Reader in Dermatology, University of Aberdeen, nominated by the British Association of Dermatologists – clinical specialist

  • Andrew Langford, Chief Executive, the Skin Care Campaign, nominated by the Skin Care Campaign – patient expert