Denosumab for the prevention of osteoporotic fractures in postmenopausal women

  • Technology appraisal guidance
  • TA204
  • Published: 
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7 Sources of evidence considered by the Committee

The Evidence Review Group (ERG) report for this appraisal was prepared by Aberdeen Health Technology Assessment Group:

  • Scotland G, Royle P, Henderson R et al. Evidence review: denosumab for the prevention of osteoporotic fractures in post-menopausal women (March 2010)

The following organisations accepted the invitation to participate in this appraisal as consultees and commentators. They were invited to comment on the draft scope, the ERG report and the appraisal consultation document (ACD). Manufacturers or sponsors were also invited to make written submissions. Professional or specialist, and patient or carer groups, and other consultees had the opportunity to give their expert views. Manufacturers or sponsors, professional or specialist and patient or carer groups and other consultees also have the opportunity to appeal against the final appraisal determination.

Manufacturer or sponsor:

  • Amgen

Professional or specialist, and patient or carer groups:

  • British Health Professionals in Rheumatology

  • British Society for Rheumatology

  • National Osteoporosis Society

  • Primary Care Rheumatology Society

  • Royal College of Nursing

  • Royal College of Pathologists

  • Royal College of Physicians

  • Royal College of Radiographers

  • Society for Endocrinology

Other consultees:

  • Coventry Teaching PCT

  • Department of Health

  • NHS North Somerset

  • Welsh Assembly Government

Commentator organisations (did not provide written evidence and without the right of appeal):

  • National Institute for Health Research Health Technology Assessment Programme

  • NHS Quality Improvement Scotland

  • Novartis

  • Pfizer

  • Roche

  • Servier

The following individuals were selected from clinical specialist and patient expert nominations from the non-manufacturer or sponsor consultees and commentators. They gave their expert personal view on denosumab by attending the initial Committee discussion and providing written evidence to the Committee. They were also invited to comment on the ACD.

  • Professor Roger Francis, Professor of Geriatric Medicine, nominated by the National Osteoporosis Society – clinical specialist

  • Professor Jon Tobias, Professor of Rheumatology and Honorary Consultant Rheumatologist, nominated by the British Society for Rheumatology – clinical specialist

  • Niki Gonty, nominated by National Osteoporosis Society – patient expert

  • Angela White, nominated by the National Osteoporosis Society – patient expert

The following individuals were nominated as NHS Commissioning experts by the selected PCT allocated to this appraisal. They gave their expert and NHS commissioning personal view on denosumab by attending the initial Committee discussion and providing written evidence to the Committee. They were also invited to comment on the ACD.

  • Debbie Campbell, Head of Medicines Management, selected by North Somerset Primary Care Trust – NHS Commissioning expert

Representatives from the following manufacturer attended Committee Meetings. They contributed only when asked by the Committee chair to clarify specific issues and comment on factual accuracy.

  • Amgen