Tocilizumab for the treatment of systemic juvenile idiopathic arthritis

  • Technology appraisal guidance
  • TA238
  • Published: 
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7 Sources of evidence considered by the Committee

The Evidence Review Group (ERG) report for this appraisal was prepared by Kleijnen Systematic Reviews Ltd:

  • Riemsma R, Al MJ, Lhachimi SK et al. Tocilizumab for the treatment of systemic juvenile idiopathic arthritis: a Single Technology Appraisal. York: Kleijnen Systematic Reviews Ltd, 2011

The following organisations accepted the invitation to participate in this appraisal as consultees and commentators. They were invited to comment on the draft scope, the ERG report and the appraisal consultation document (ACD). Manufacturers or sponsors were also invited to make written submissions. Professional or specialist, patient or carer groups, and other consultees, had the opportunity to give their expert views. Manufacturers or sponsors, professional or specialist, patient or carer groups, and other consultees, also have the opportunity to appeal against the final appraisal determination.

Manufacturers or sponsors:

  • Roche Products

Professional or specialist, and patient or carer groups:

  • Arthritis Care

  • National Rheumatoid Arthritis Society

  • South Asian Health Foundation

  • British Health Professionals in Rheumatology

  • British Society for Paediatric and Adolescent Rheumatology

  • British Society for Rheumatology

  • Royal College of Nursing

  • Royal College of Paediatrics and Child Health

  • Royal College of Pathologists

  • Royal College of Physicians

Other consultees:

  • Department of Health

  • Welsh Government

Commentator organisations (did not provide written evidence and without the right of appeal):

  • British National Formulary

  • Commissioning Support Appraisals Service

  • Department of Health, Social Services and Public Safety for Northern Ireland

  • Healthcare improvement Scotland

  • Abbott

  • Pfizer–Wyeth

  • Schering-Plough

  • Swedish Orphan Biovitrum Ltd

  • Arthritis Research UK

  • Kleijnen Systematic Reviews Ltd

  • National Coordinating Centre for Health Technology Assessment

The following individuals were selected from clinical specialist and patient expert nominations from the non-manufacturer or sponsor consultees and commentators. They gave their expert personal view on tocilizumab for the treatment of systemic juvenile idiopathic arthritis by attending the initial Committee discussion and providing written evidence to the Committee. They were also invited to comment on the ACD.

  • Dr Jeremy Camilleri, Consultant Rheumatologist, nominated by the Welsh Government – clinical specialist

  • Dr Mark Wood, Consultant Paediatric Rheumatologist, nominated by the British Society of Paediatric and Adolescent Rheumatology – clinical specialist

  • Dr Gavin Cleary, nominated by the British Society of Paediatric and Adolescent Rheumatology – clinical specialist

  • Helen Copeland, nominated by the National Rheumatoid Arthritis Society – patient expert

  • Sarah Gebbie, nominated by the National Rheumatoid Arthritis Society – patient expert

Representatives from the following manufacturer or sponsor attended Committee meetings. They contributed only when asked by the Committee chair to clarify specific issues and comment on factual accuracy.

  • Roche Products