Bortezomib for induction therapy in multiple myeloma before high-dose chemotherapy and autologous stem cell transplantation

  • Technology appraisal guidance
  • TA311
  • Published: 
Download guidance (PDF)

7 Sources of evidence considered by the Committee

The Evidence Review Group (ERG) report for this appraisal was prepared by Southampton Technology Assessment Centre:

  • Cooper K, Hartwell D, Copley V et al. Bortezomib for induction therapy in multiple myeloma before high dose chemotherapy and autologous stem cell transplantation: A Single Technology Appraisal. SHTAC. May 2013

The following organisations accepted the invitation to participate in this appraisal as consultees and commentators. They were invited to comment on the draft scope, the ERG report and the appraisal consultation document (ACD). Manufacturers or sponsors were also invited to make written submissions. Professional or specialist and patient or carer groups, and other consultees, had the opportunity to give their expert views. Manufacturers or sponsors, professional or specialist and patient or carer groups, and other consultees, also have the opportunity to appeal against the final appraisal determination.

Manufacturers or sponsors:

  • Janssen

Professional or specialist and patient or carer groups:

  • Myeloma UK

  • South Asian Health Foundation

  • British Society of Haematology

  • Cancer Research UK

  • Royal College of Nursing

  • Royal College of Pathologists

  • Royal College of Physicians

  • UK Myeloma Forum

Other consultees:

  • Department of Health

  • Welsh Government

Commentator organisations (did not provide written evidence and without the right of appeal):

  • Commissioning Support Appraisals Service

  • Department of Health, Social Services and Public Safety for Northern Ireland

  • Healthcare Improvement Scotland

  • Medicines and Healthcare products Regulatory Agency

  • Celgene

  • Pfizer

  • National Cancer Research Institute

  • Southampton Health Technology Assessment Centre (SHTAC)

  • National Institute for Health Research Health Technology Assessment Programme

  • National Collaborating Centre for Cancer

The following individuals were selected from clinical specialist and patient expert nominations from the consultees and commentators. They gave their expert personal view on bortezomib by attending the initial Committee discussion and providing written evidence to the Committee. They were also invited to comment on the ACD.

  • Dr Jenny Bird, Consultant Haematologist, nominated by Royal College of Pathologists and British Society of Haematology – clinical specialist

  • Professor Kwee Yong, Consultant Haematologist, nominated by UK Myeloma Forum, Royal College of Pathologists and British Society of Haematology – clinical specialist

  • Eric Low, Chief Executive, nominated by UK Myeloma Forum – patient expert

  • Stuart Fullerton, nominated by UK Myeloma Forum – patient expert

Representatives from the following manufacturer or sponsor attended Committee meetings. They contributed only when asked by the Committee chair to clarify specific issues and comment on factual accuracy.

  • Janssen

ISBN 978-1-4731-0557-7