2 Summary of NICE recommendations
NICE technology appraisal guidance on sacubitril valsartan for treating symptomatic chronic heart failure with reduced ejection fraction[1] recommends it as an option for treating symptomatic chronic heart failure in people:
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with New York Heart Association (NYHA) class II to IV symptoms and
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with a left ventricular ejection fraction of 35% or less and
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who are already taking a stable dose of angiotensin‑converting enzyme (ACE) inhibitors or ARBs.
Treatment with sacubitril valsartan should be started by a heart failure specialist with access to a multidisciplinary heart failure team. Dose titration and monitoring should be performed by the most appropriate team member as defined in NICE's guideline on chronic heart failure in adults: management.
[1] The guidance is not intended to affect the position of patients whose treatment with sacubitril valsartan was started within the NHS before this guidance was published. Treatment of those patients may continue without change to whatever funding arrangements were in place for them before this guidance was published until they and their NHS clinician consider it appropriate to stop (recommendation 1.3).