Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer

The appraisal committee (section 6) considered evidence submitted by Pfizer and a review of this submission by the evidence review group. This appraisal was a Cancer Drugs Fund reconsideration of the published NICE technology appraisal guidance on crizotinib for previously treated non-small-cell lung cancer associated with an anaplastic lymphoma kinase fusion gene. It focused on cost-effectiveness analyses using a revised patient access scheme, which provides a simple discount to the list price of crizotinib. The level of the discount is commercial in confidence.

See the committee papers for full details of the Cancer Drugs Fund reconsideration evidence and the history for full details of the evidence used for NICE's original technology appraisal guidance on crizotinib for previously treated non-small-cell lung cancer associated with an anaplastic lymphoma kinase fusion gene.